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Autophagy at synapses in neurodegenerative diseases

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Abstract

Autophagy is an essential process for maintaining cellular homeostasis, a critical process in all cell types. Because neurons are post-mitotic cells, maintaining cellular and functional homeostasis is more important in neurons than in other types of cells. Synapses are fundamental units needed for neural communication, and synapses with consistent protein quality are essential for neural functionality. Dysregulation of autophagy in neurons has been shown to be related to neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. This review describes the role of autophagy in the maintenance of synaptic functionality and the association between synaptic autophagy and neurodegenerative diseases.

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Acknowledgements

We thank Soondo Hwang, Soulmee Koh, and Do Ru Kwon from the Synapse Communication Laboratory for their valuable comments. This work was supported by the National Research Foundation of Korea (2017M3C7A1048268, 2017R1A2B4007019, 2018R1A6A1A03025124).

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  1. Department of Neuroscience, Graduate School, Kyung Hee University, Seoul, 02447, South Korea

    Wongyoung Lee

  2. Department of Physiology, School of Medicine, Kyung Hee University, Seoul, 02447, South Korea

    Sung Hyun Kim

  3. Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, 02447, South Korea

    Sung Hyun Kim

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Lee, W., Kim, S.H. Autophagy at synapses in neurodegenerative diseases. Arch. Pharm. Res. 42, 407–415 (2019). https://doi.org/10.1007/s12272-019-01148-7

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