Cytotoxic isocoumarin derivatives from the mangrove endophytic fungus Aspergillus sp. HN15-5D
- 179 Downloads
Five isocoumarin derivatives including three new compounds, aspergisocoumrins A–C (1–3), together with two known analogues, 8-dihydroxyisocoumarin-3-carboxylic acid (4) and dichlorodiaportin (5) were obtained from the culture of the endophytic fungus Aspergillus sp. HN15-5D derived from the fresh leaves of the mangrove plant Acanthus ilicifolius. Their structures were elucidated using comprehensive spectroscopic methods. The double bond geometry of compounds 1 and 2 were assigned as E and Z on the basis of the distinct coupling constants, respectively. Compounds 1 and 2 showed cytotoxicity against MDA-MB-435 with IC50 values of 5.08 ± 0.88 and 4.98 ± 0.74 μM, respectively.
KeywordsIsocoumarins Cytotoxicity Aspergillus sp. Mangrove endophytic fungus
We thank the National Natural Science Foundation of China (21472251, 41404134), the Science & Technology Plan Project of Guangdong Province of China (2013B021100021), Natural Science Program of Guangdong Province (2016A030313588) and the Key Project of Natural Science Foundation of Guangdong Province (2016A040403091) for generous support.
Compliance with ethical standards
Conflict of interest
The authors declare no conflict of interest.
- Abd El-Hady FK, Abdel-Aziz MS, Shaker KH, El-Shahid ZA, Ibrahim LS (2015) Antioxidant, acetylcholinesterase and α-glucosidase potentials of metabolites from the marine fungus Aspergillus unguis RSPG_204 associated with the sponge (Agelas sp.). Int J Pharm Sci Rev Res 30:272–278Google Scholar
- Glauser G, Gindro K, Fringeli J, De Joffrey JP, Rudaz S, Wolfender JL (2009) Differential analysis of mycoalexins in confrontation zones of grapevine fungal pathogens by ultrahigh pressure liquid chromatography/time-of-flight mass spectrometry and capillary nuclear magnetic resonance. J Agr Food Chem 57:1127–1134CrossRefGoogle Scholar
- Hill RA (1986) Naturally occurring isocoumarins. In: Progress in the Chemistry of Organic Natural Products. Springer, Vienna, pp 1–78Google Scholar