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Cytotoxic isocoumarin derivatives from the mangrove endophytic fungus Aspergillus sp. HN15-5D

  • Yingnan Wu
  • Senhua Chen
  • Hongju Liu
  • Xishan Huang
  • Yayue Liu
  • Yiwen Tao
  • Zhigang She
Research Article
  • 179 Downloads

Abstract

Five isocoumarin derivatives including three new compounds, aspergisocoumrins A–C (13), together with two known analogues, 8-dihydroxyisocoumarin-3-carboxylic acid (4) and dichlorodiaportin (5) were obtained from the culture of the endophytic fungus Aspergillus sp. HN15-5D derived from the fresh leaves of the mangrove plant Acanthus ilicifolius. Their structures were elucidated using comprehensive spectroscopic methods. The double bond geometry of compounds 1 and 2 were assigned as E and Z on the basis of the distinct coupling constants, respectively. Compounds 1 and 2 showed cytotoxicity against MDA-MB-435 with IC50 values of 5.08 ± 0.88 and 4.98 ± 0.74 μM, respectively.

Keywords

Isocoumarins Cytotoxicity Aspergillus sp. Mangrove endophytic fungus 

Notes

Acknowledgements

We thank the National Natural Science Foundation of China (21472251, 41404134), the Science & Technology Plan Project of Guangdong Province of China (2013B021100021), Natural Science Program of Guangdong Province (2016A030313588) and the Key Project of Natural Science Foundation of Guangdong Province (2016A040403091) for generous support.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

Supplementary material

12272_2018_1019_MOESM1_ESM.docx (859 kb)
Supplementary material 1 (DOCX 858 kb)

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Copyright information

© The Pharmaceutical Society of Korea 2018

Authors and Affiliations

  1. 1.School of ChemistrySun Yat-Sen UniversityGuangzhouChina
  2. 2.College of Food Science and TechnologyGuangdong Ocean UniversityZhanjiangChina
  3. 3.South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation CenterGuangzhouChina

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