Phenolic amides from Tribulus terrestris and their inhibitory effects on nitric oxide production in RAW 264.7 cells
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A new phenolic amide, named cis-terrestriamide (7), together with ten known compounds (1–6, 8–11), were isolated from the methanolic extract of the fruits of Tribulus terrestris. The structure of 7 was elucidated on the basis of extensive analyses of 1D and 2D nuclear magnetic resonance spectroscopic and high resolution mass spectrometry data. Compounds 1, 2, 5, 6, 8, 9, and 11 exhibited inhibitory effects on the lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 cells, with IC50 values of 18.7–49.4 μM.
KeywordsTribulus terrestris Zygophyllaceae Phenolic amide, Nitric oxide production inhibitor
This work was supported by the Medical Research Center Program (MRC, 2017R1A5A2015541) through the National Research Foundation of Korea and by the intramural research grant of Chungbuk National University in 2015.
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