Pyrazinone derivatives from the coral-derived Aspergillus ochraceus LCJ11-102 under high iodide salt
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Five new pyrazin-2(1H)-one derivatives, ochramides A–D (1–4) and ochralate A (5), as well as three known analogues (6–8) were isolated from the fermentation broth of the marine coral-derived halotolerant Aspergillus ochraceus LCJ11-102 in a nutrient-limited medium containing 10% NaI. Their chemical structures were determined by analyzing NMR and X-ray diffraction data. Compounds 2, 5 and 6 showed antimicrobial activities against Enterobacter aerogenes with the MIC values of 40.0, 18.9, and 20.1 μM, respectively.
KeywordsCoral Halotolerant fungus Aspergillus ochraceus Antibacterial activity Aluminum chelates
This work was supported by Grants from National Natural Science Foundation of China (Nos. 41376148, 81373298, U1501221, 81561148012 and U1406402-1), and from Special Fund for Marine Scientific Research in the Public Interest of China (No. 201405038). The working strain LCJ11-102 was identified by Prof. C. X. Fang, China Center for Type Culture Collection. The X-ray single crystal diffraction data analysis was performed by Prof. Dr. Zhiyong Wu.
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Conflict of interest
The authors have declared that there is no conflict of interest.
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