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Multiple biological properties of macelignan and its pharmacological implications

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Abstract

Macelignan found in the nutmeg mace of Myristica fragrans obtains increasing attention as a new avenue in treating various diseases. Macelignan has been shown to possess a spectrum of pharmacological activities, including anti-bacterial, anti-inflammatory, anti-cancer, anti-diabetes, and hepatoprotective activities; recently, it has also been shown to have neuroprotective activities. This review summarizes the current research on the biological effects of macelignan derived from M. fragrans, with emphasis on the importance in understanding and treating complex diseases such as cancer and Alzheimer’s disease.

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This paper was supported by Konkuk University research support program (2011)

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Authors and Affiliations

  1. Department of Biological Sciences, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul, 143-701, South Korea

    Saswati Paul, ChiHye Chung & Jung-Soo Han

  2. Department of Biotechnology, Yonsei University, Seoul, 120-752, South Korea

    Jae Kwan Hwang

  3. Department of Neurology, Konkuk University Hospital, Center for Geriatric Neuroscience Research, IBST, Konkuk University, Seoul, 143-729, South Korea

    Hahn Young Kim

  4. Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, 305-811, South Korea

    Won Kyung Jeon

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Paul, S., Hwang, J.K., Kim, H.Y. et al. Multiple biological properties of macelignan and its pharmacological implications. Arch. Pharm. Res. 36, 264–272 (2013). https://doi.org/10.1007/s12272-013-0048-z

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