In enzymes, the active site is the location where substrates are chemically converted. If this site is deeply buried within the protein, substrates must pass not only through the body of the protein via a tunnel, but also flexible, site-decorating loops to access the active site. These elements can act as filters that influence on both substrate specificity and activity. Identifying and understanding how they exert such control has been of growing interest over the past several years.
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Peter M. Heinemann, Lea R. Rapp und Bernhard Hauer (von oben nach unten).
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Heinemann, P.M., Rapp, L.R. & Hauer, B. Loops und Tunnel: unterschätzte Elemente in Enzymen. Biospektrum 26, 434–436 (2020). https://doi.org/10.1007/s12268-020-1394-2