Abstract
Environmental factors harbor capacity to modulate onset and progression of Parkinson’s disease. To identify genes transducing beneficial environmental cues into the genomic program, we examined environment-induced changes in hippocampal gene activity of mice overexpressing human SNCA, an aetiological key gene. Our results point to an environment-inducible gene network that prevented SNCA-dependent disturbances in gene activity and might aid in identifying novel therapeutic opportunities.
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Alexander Kilzheimer Seit 2012 Humanmedizin- und Psychologiestudium an den Universitäten Konstanz und Tübingen. Seit 2018 Promotionsstudium am Institut für Medizinische Genetik und Angewandte Genomik, Universitätsklinikum Tübingen.
Julia Schulze-Hentrich 2000–2005 Biologiestudium an den Universitäten Göttingen und Jena. 2006–2011 Promotion und Postdoctoral Fellow an der University of British Columbia, Vancouver, Kanada. Seit 2012 Arbeitsgruppenleiterin am Institut für Medizinische Genetik und Angewandte Genomik am Universitätsklinikum Tübingen mit dem Forschungsschwerpunkt Epigenomik neurodegenerativer Erkrankungen.
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Kilzheimer, A., Schulze-Hentrich, J. Schutzmechanismen der Gen-Umwelt-Achse in Morbus Parkinson. Biospektrum 24, 604–607 (2018). https://doi.org/10.1007/s12268-018-0965-y
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DOI: https://doi.org/10.1007/s12268-018-0965-y