Abstract
The essential tRNA processing enzyme RNase P consists of a catalytic RNA and a small protein in most Bacteria. An RNA was also identified in archaeal and many eukaryal nuclear RNases P, with five protein cofactors in Archaea and nine or ten in Eukarya. Yet, more recently, the second RNase P in human cells, acting in mitochondria, was found to lack an RNA; this type of protein-only RNase P is also wide-spread among euka - ryotes. Moreover, we recently discovered a novel RNA-free RNase P in the hyperthermophilic bacterium Aquifex aeolicus, consisting of a single polypeptide of 23 kilodaltons.
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Astrid I. Nickel 2002–2006 Pharmaziestudium an der Universität Marburg. 2008 Approbation als Apothekerin. 2008–2014 Promotion an der Universität Marburg. 2014–2015 Postdoc an der Universität Marburg. Seit 2016 Mitarbeiterin der Haupt Pharma Wülfing GmbH (Aenova Group), Gronau/Leine.
Isabell Schencking 2011–2015 Pharmaziestudium an der Universität Marburg. 2016 Approbation als Apothekerin. Seit 2017 Promotion am Institut für Pharmazeutische Chemie der Universität Marburg.
Nadine B. Wäber 2007–2010 Biologiestudium an der Universität Marburg mit Schwerpunkt Mikrobiologie. 2011–2013 Masterstudium am Karlsruher Institut für Technologie (KIT) mit den Schwerpunkten Genetik, Molekularund Mikrobiologie. Seit 2014 Promotion am Institut für Pharmazeutische Chemie der Universität Marburg.
Markus Gößringer 1990–1996 Biologiestudium (Diplom) an der Universität Konstanz. 1999–2004 Promotion an den Universitäten Lübeck und Marburg. Seit 2004 Postdoc am Institut für Pharmazeutische Chemie der Universität Marburg.
Roland K. Hartmann 1976–1981 Biochemiestudium an der FU Berlin, dort 1983–1987 Promotion. 1988 Ernst-Reuter-Preis für hervorragende Dissertationen. 1995–2003 Arbeitsgruppenleiter am Institut für Biochemie der Universität Lübeck. Seit 2003 Professur für Pharmazeutische Chemie an der Universität Marburg.
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Nickel, A.I., Wäber, N.B., Gößringer, M. et al. Minimale RNA-freie RNase P in einem hyperthermophilen Bakterium. Biospektrum 24, 582–585 (2018). https://doi.org/10.1007/s12268-018-0960-3
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DOI: https://doi.org/10.1007/s12268-018-0960-3