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Genetische Aspekte bei Alkoholismus

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Abstract

Studies in twins demonstrate major genetic influences in the development of alcohol use disorders (AUD) such as addiction. Candidate studies and genome-wide association studies (GWAS) have identified numerous candidate genes for excessive alcohol consumption and AUD. Here we present a convergent functional genetics approach which is a translational methodology that integrates multiple lines of evidence from studies in human and animal models to get a better understanding of the genetics of AUD.

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Authors and Affiliations

  1. Abteilung für Genetische Epidemiologie in der Psychiatrie, Zentralinstitut für Seelische Gesundheit, Medizinische Fakultät, Mannheim der Universität Heidelberg, Heidelberg, Deutschland

    Jens Treutlein

  2. Institut für Psychopharmakologie, Zentralinstitut für Seelische Gesundheit, Medizinische Fakultät, Mannheim der Universität Heidelberg, Heidelberg, Deutschland

    Rainer Spanagel

  3. Zentralinstitut für Seelische Gesundheit Medizinische Fakultät, Mannheim der Universität Heidelberg, J5, D-68159, Mannheim, Deutschland

    Jens Treutlein & Rainer Spanagel

Authors
  1. Jens Treutlein
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  2. Rainer Spanagel
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Corresponding authors

Correspondence to Jens Treutlein or Rainer Spanagel.

Additional information

Jens Treutlein1992–1998 Biologiestudium in Heidelberg. 1999–2002 Doktorarbeit (PhD) am Institut für Pharmazie und Molekulare Biotechnologie (IPMB), Universität Heidelberg. 2002–2003 Postdoc am Institut für Pharmazie und Molekulare Biotechnologie, Universität Heidelberg. Seit 2004 wissenschaftlicher Mitarbeiter im molekulargenetischen Labor, Abteilung Genetische Epidemiologie in der Psychiatrie, Zentralinstitut für Seelische Gesundheit, Mannheim.

Rainer Spanagel 1982–1989 Biologiestudium in Tübingen und München. 1989–1991 Doktorarbeit (PhD) am Max-Planck-Institut (MPI) für Psychiatrie, Martinsried (Abteilung Neuropharmakologie). 1991–1995 Postdoc am MPI für Psychiatrie, Klinisches Institut, München. 1996–1999 Leiter der Arbeitsgruppe Suchtforschung am MPI für Psychiatrie. 1996–1997 Habilitation an der LMU München. 2000–2011 Professur für Psychopharmakologie und Abteilungsleiter der Psychopharmakologie am Zentralinstitut für Seelische Gesundheit, Mannheim; dort seit 2011 wissenschaftlicher Direktor des Instituts für Psychopharmakologie.

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Treutlein, J., Spanagel, R. Genetische Aspekte bei Alkoholismus. Biospektrum 24, 260–263 (2018). https://doi.org/10.1007/s12268-018-0916-7

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  • DOI: https://doi.org/10.1007/s12268-018-0916-7

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