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BIOspektrum

, Volume 24, Issue 3, pp 256–259 | Cite as

Synthese von schwefelhaltigen Metallkofaktoren und Thionukleosiden in tRNA

  • Lena Beilschmidt
  • Martin Bühning
  • Silke Leimkühler
Wissenschaft Schwefelstoffwechsel
  • 13 Downloads

Abstract

The synthesis of sulfur-containing biomolecules is a complex process that involves the activation of sulfur. In particular, L-cysteine desulfurases serve as primary sulfur-providing proteins for biomolecules including Fe-S clusters, thiamin, biotin, lipoic acid, molybdenum cofactor (Moco), and thiolated nucleosides in tRNA. The pathways for the sulfur insertion for Fe-S cluster assembly, Moco biosynthesis and thiomodifications of tRNA are introduced and common principles are revealed.

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Literatur

  1. [1]
    Leimkühler S, Bühning M, Beilschmidt L (2017) Shared sulfur mobilization routes for tRNA thiolation and molybdenum cofactor biosynthesis in prokaryotes and eukaryotes. Biomolecules 7, doi: 10.3390/biom7010005Google Scholar
  2. [2]
    Black KA, Dos Santos PC (2015) Shared-intermediates in the biosynthesis of thio-cofactors: mechanism and functions of cysteine desulfurases and sulfur acceptors. Biochim Biophys Acta 1853:1470–1480CrossRefPubMedGoogle Scholar
  3. [3]
    Roche B, Aussel L, Ezraty B et al. (2013) Iron/sulfur proteins biogenesis in prokaryotes: formation, regulation and diversity. Biochim Biophys Acta 1827:455–469CrossRefPubMedGoogle Scholar
  4. [4]
    Leimkühler S, Iobbi-Nivol C (2016) Bacterial molybdoenzymes: old enzymes for new purposes. FEMS Microbiol Rev 40:1–18CrossRefPubMedGoogle Scholar
  5. [5]
    Mendel RR, Leimkühler S (2015) The biosynthesis of the molybdenum cofactors. J Biol Inorg Chem 20:337–347CrossRefPubMedGoogle Scholar
  6. [6]
    Shigi N (2014) Biosynthesis and functions of sulfur modifications in tRNA. Front Genet 5:67CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2018

Authors and Affiliations

  • Lena Beilschmidt
    • 1
  • Martin Bühning
    • 1
  • Silke Leimkühler
    • 1
  1. 1.Institut für Biochemie und BiologieUniversität PotsdamPotsdamDeutschland

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