, Volume 24, Issue 3, pp 256–259 | Cite as

Synthese von schwefelhaltigen Metallkofaktoren und Thionukleosiden in tRNA

  • Lena Beilschmidt
  • Martin Bühning
  • Silke Leimkühler
Wissenschaft Schwefelstoffwechsel


The synthesis of sulfur-containing biomolecules is a complex process that involves the activation of sulfur. In particular, L-cysteine desulfurases serve as primary sulfur-providing proteins for biomolecules including Fe-S clusters, thiamin, biotin, lipoic acid, molybdenum cofactor (Moco), and thiolated nucleosides in tRNA. The pathways for the sulfur insertion for Fe-S cluster assembly, Moco biosynthesis and thiomodifications of tRNA are introduced and common principles are revealed.


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Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2018

Authors and Affiliations

  • Lena Beilschmidt
    • 1
  • Martin Bühning
    • 1
  • Silke Leimkühler
    • 1
  1. 1.Institut für Biochemie und BiologieUniversität PotsdamPotsdamDeutschland

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