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BIOspektrum

, Volume 24, Issue 3, pp 253–255 | Cite as

Links- oder Rechtshänder? – Die molekularen Grundlagen der Händigkeit

  • Judith Schmitz
  • Stephanie Lor
  • Onur Güntürkün
  • Sebastian Ocklenburg
Wissenschaft Lateralisierung

Abstract

Handedness is one of the most prominent functional hemispheric asymmetries. Initially thought to be determined by a single gene, molecular genetic studies have shown that it is influenced by multiple genes. Recent research indicates that epigenetic regulation induces asymmetrical gene expression in the embryonic spinal cord, potentially leading to motor asymmetries. An integration of multiple genetic, epigenetic, and environmental factors is essential to fully comprehend handedness ontogenesis.

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Literatur

  1. [1]
    Schmitz J, Metz GAS, Güntürkün O et al. (2017) Beyond the genome–Towards an epigenetic understanding of handedness ontogenesis. Prog Neurobiol 159:69–89CrossRefPubMedGoogle Scholar
  2. [2]
    Ocklenburg S, Beste C, Arning L (2014) Handedness genetics. Front Psychol 5:1300PubMedPubMedCentralGoogle Scholar
  3. [3]
    Armour JAL, Davison A, McManus IC (2014) Genome-wide association study of handedness excludes simple genetic models. Heredity 112:221–225CrossRefPubMedGoogle Scholar
  4. [4]
    Eriksson N, Macpherson JM, Tung JY et al. (2010) Web-based, participant-driven studies yield novel genetic associations for common traits. PLoS Genet 6:e1000993CrossRefGoogle Scholar
  5. [5]
    Somers M, Ophoff RA, Aukes MF et al. (2015) Linkage analysis in a Dutch population isolate shows no major gene for left-handedness or atypical language lateralization. J Neurosci 35:8730–8736CrossRefPubMedPubMedCentralGoogle Scholar
  6. [6]
    Ocklenburg S, Beste C, Güntürkün O (2013) Handedness: a neurogenetic shift of perspective. Neurosci Biobehav Rev 37:2788–2793CrossRefPubMedGoogle Scholar
  7. [7]
    Brandler WM, Paracchini S (2014) The genetic relationship between handedness and neurodevelopmental disorders. Trends Mol Med 20:83–90CrossRefPubMedPubMedCentralGoogle Scholar
  8. [8]
    Medland SE, Duffy DL, Wright MJ et al. (2006) Handedness in twins. Twin Res Hum Genet 9:46–53CrossRefPubMedGoogle Scholar
  9. [9]
    Sun T, Patoine C, Abu-Khalil A et al. (2005) Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. Science 308:1794–1798CrossRefPubMedPubMedCentralGoogle Scholar
  10. [10]
    Ocklenburg S, Schmitz J, Moinfar Z et al. (2017) Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries. Elife 6, doi: 10.7554/eLife.22784Google Scholar
  11. [11]
    Leach EL, Prefontaine G, Hurd PL et al. (2014) The imprinted gene LRRTM1 mediates schizotypy and handedness in a nonclinical population. J Hum Genet 59:332–336CrossRefPubMedGoogle Scholar
  12. [12]
    Schmitz J, Kumsta R, Moser D et al. (2017) DNA methylation in candidate genes for handedness predicts handedness direction. Laterality 23:441–461CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2018

Authors and Affiliations

  • Judith Schmitz
    • 1
    • 2
  • Stephanie Lor
    • 1
  • Onur Güntürkün
    • 1
  • Sebastian Ocklenburg
    • 1
  1. 1.Biopsychologie, Fakultät für PsychologieRuhr-Universität BochumBochumDeutschland
  2. 2.Abteilung Biopsychologie Institut für Kognitive Neurowissenschaft Fakultät für PsychologieRuhr-Universität BochumBochumDeutschland

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