Das Mikromilieu beeinflusst das Zellschicksal von Keimzelltumoren
Testicular germ cell cancers are subdivided into seminomas and non-seminomas. Here, we summarize how different cellular microenvironments affect the cell fate of seminomas. Further, we describe the molecular mechanisms driving a reprogramming into an embryonal carcinoma (the stem cell population of the non-seminomas) and differentiation into a mixed non-seminoma. Our results may explain how non-seminomas develop that contain a seminoma component, which are often observed in clinical routine.
Unable to display preview. Download preview PDF.