, Volume 23, Issue 7, pp 779–781 | Cite as

Das Mikromilieu beeinflusst das Zellschicksal von Keimzelltumoren

Wissenschaft · Special: Molekulare Diagnostik Zellplastizität


Testicular germ cell cancers are subdivided into seminomas and non-seminomas. Here, we summarize how different cellular microenvironments affect the cell fate of seminomas. Further, we describe the molecular mechanisms driving a reprogramming into an embryonal carcinoma (the stem cell population of the non-seminomas) and differentiation into a mixed non-seminoma. Our results may explain how non-seminomas develop that contain a seminoma component, which are often observed in clinical routine.


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Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2017

Authors and Affiliations

  1. 1.Institut für Pathologie, Abteilung EntwicklungspathologieUniversitätsklinikum BonnBonnDeutschland

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