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Das Mikromilieu beeinflusst das Zellschicksal von Keimzelltumoren

  • Wissenschaft · Special: Molekulare Diagnostik
  • Zellplastizität
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Abstract

Testicular germ cell cancers are subdivided into seminomas and non-seminomas. Here, we summarize how different cellular microenvironments affect the cell fate of seminomas. Further, we describe the molecular mechanisms driving a reprogramming into an embryonal carcinoma (the stem cell population of the non-seminomas) and differentiation into a mixed non-seminoma. Our results may explain how non-seminomas develop that contain a seminoma component, which are often observed in clinical routine.

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Authors and Affiliations

  1. Institut für Pathologie, Abteilung Entwicklungspathologie, Universitätsklinikum Bonn, Sigmund-Freud-Straße 25, D-53127, Bonn, Deutschland

    Daniel Nettersheim & Hubert Schorle

Authors
  1. Daniel Nettersheim
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  2. Hubert Schorle
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Correspondence to Daniel Nettersheim.

Additional information

Daniel Nettersheim Jahrgang 1980. 2000–2005 Bioingenieurwesenstudium an der Fachhochschule Jülich. 2005–2006 wissenschaftlicher Mitarbeiter an der Fachhochschule Bonn-Rhein-Sieg. Seit 2006 wissenschaftlicher Mitarbeiter in der Abteilung für Entwicklungspathologie am Institut für Pathologie, Uniklinikum Bonn. 2006–2010 Promotion (Dr. rer. nat., Molekulare Biomedizin) an der Universität Bonn. 2011–2016 Habilitation an der Medizinischen Fakultät der Universität Bonn (Molekulare Pathologie).

Hubert Schorle Jahrgang 1962. 1983–1989 Biologiestudium an der Universität Würzburg. 1989–1991 Promotion. 1992–1996 Postdoc am Whitehead Institute/Massachusetts Institute of Technology, Boston, MA, USA. 1997–2001 Gruppenleiter am Karlsruher Institut für Technologie (KIT). 2001–2004 Oberassistent am Institut für Pathologie, Uniklinikum Bonn. 2004 Professor am Zentrum für Medizinische Biotechnologie (ZMB), Universität Duisburg-Essen. Seit 2005 Professor und Leiter der Abteilung Entwicklungspathologie am Institut für Pathologie, Uniklinikum Bonn.

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Nettersheim, D., Schorle, H. Das Mikromilieu beeinflusst das Zellschicksal von Keimzelltumoren. Biospektrum 23, 779–781 (2017). https://doi.org/10.1007/s12268-017-0873-6

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  • DOI: https://doi.org/10.1007/s12268-017-0873-6

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