Engineering von intrazellulären Modulatoren
- 42 Downloads
The engineering of affinity reagents has become a standard technology in modern drug development efforts. High-throughput screening of recombinant protein libraries has yielded numerous affinity reagents that are used in diagnostic or therapeutic applications. In our approach, we engineer intracellular affinity reagents by enhancing pre-existing intermolecular contacts to target functional epitopes in proteins. The designed affinity reagents allow a fast and specific interrogation of druggable sites in therapeutic relevant proteins.
Unable to display preview. Download preview PDF.
- Wiechmann S, Gartner A, Kniss A, et al. (2017) Site-specific inhibition of the SUMO-conjugating enzyme Ubc9 selectively impairs SUMO chain formation. J Biol Chem, DOI:10.1074/ibc.M117.794255Google Scholar