, Volume 23, Issue 7, pp 766–768 | Cite as

Zirkulierende Tumorzellen - voll automatisierte Vereinzelung aus Blut

  • Sabine Alebrand
  • Christian Freese
  • Tobias Schunck
  • Michael Bassler
Wissenschaft · Methoden Liquid biopsy


Circulating tumor cells (CTCs) are interesting for both, cancer diagnostics and therapy. Hence for practical use, very efficient methods are required to enrich, detect and isolate the typically very low number of CTCs. Herein, we present the “CTCelect device”, enabling the fully automated counting and isolation of CTCs from a blood sample for further biological investigations.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [1]
    Sun X, Zhang H (2006) Clinicopathological significance of stromal variables: angiogenesis, lymphangiogenesis, inflammatory infiltration, MMP and PINCH in colorectal carcinomas. Mol Cancer 5:43CrossRefPubMedPubMedCentralGoogle Scholar
  2. [2]
    Joosse SA, Gorges TM, Pantel K (2015) Biology, detection, and clinical implications of circulating tumor cells. EMBO Mol Med 7:1–11CrossRefPubMedGoogle Scholar
  3. [3]
    Nole F, Munzone E, Zorzino L et al. (2008) Variation of circulating tumor cell levels during treatment of metastatic breast cancer: Prognostic and therapeutic implications. Ann Oncol 19:891–897CrossRefPubMedGoogle Scholar
  4. [4]
    Cristofanilli M, Budd GT, Ellis MJ et al. (2004) Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 351:781–791CrossRefPubMedGoogle Scholar
  5. [5]
    Krebsinformationsdienst, Deutsches Krebsforschungszentrum 2016 Informationsblatt: Liquid Biopsy. Scholar
  6. [6]
    Alix-Panabières C, Pantel K (2013) Circulating tumor cells: liquid biopsy of cancer. Clin Chem 59:110CrossRefPubMedGoogle Scholar
  7. [7]
    Vladimer GI, Snijder B, Krall N et al. (2017) Global survey of the immunomodulatory potential of common drugs. Nat Chem Biol 13:681–690CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2017

Authors and Affiliations

  1. 1.Fraunhofer ICT-IMMMainzDeutschland

Personalised recommendations