Abstract
Adaptation to changing physiological conditions requires continuous adjustment of endoplasmic reticulum (ER) capacity. Cells have evolved elegant mechanisms to enlarge and shrink their ER according to need. An ER-localized monitoring system senses insufficient protein folding capacity and activates ER biogenesis to expand the organelle. Furthermore, cells dispose of excess or damaged ER by selective autophagy (ER-phagy). Together, these mechanisms ensure ER homeostasis and proper cell function.
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Jasmin Schäfer 2005–2008 Ausbildung zur Biologielaborantin. 2008–2014 Biochemiestudium in Frankfurt am Main. Seit 2014 Doktorarbeit am Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) im Labor von Dr. S. Schuck.
Sebastian Schuck 1995–2000 Biochemiestudium in Hannover und Tübingen. 2001–2006 Doktorarbeit am Max-Planck-Institut für molekulare Zellbiologie und Genetik, Dresden, im Labor von Prof. Dr. K. Simons. 2006–2013 Postdoktorand an der University of California, San Francisco, im Labor von Prof. Dr. P. Walter. Seit 2013 Gruppenleiter am Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH).
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Schäfer, J.A., Schuck, S. Biogenese und Autophagie des Endoplasmatischen Retikulums. Biospektrum 23, 762–764 (2017). https://doi.org/10.1007/s12268-017-0868-3
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DOI: https://doi.org/10.1007/s12268-017-0868-3