, Volume 23, Issue 7, pp 762–764 | Cite as

Biogenese und Autophagie des Endoplasmatischen Retikulums

  • Jasmin A. Schäfer
  • Sebastian Schuck
Wissenschaft Organellhomöostase


Adaptation to changing physiological conditions requires continuous adjustment of endoplasmic reticulum (ER) capacity. Cells have evolved elegant mechanisms to enlarge and shrink their ER according to need. An ER-localized monitoring system senses insufficient protein folding capacity and activates ER biogenesis to expand the organelle. Furthermore, cells dispose of excess or damaged ER by selective autophagy (ER-phagy). Together, these mechanisms ensure ER homeostasis and proper cell function.


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Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2017

Authors and Affiliations

  1. 1.Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH)HeidelbergDeutschland

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