Biogenese und Autophagie des Endoplasmatischen Retikulums
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Adaptation to changing physiological conditions requires continuous adjustment of endoplasmic reticulum (ER) capacity. Cells have evolved elegant mechanisms to enlarge and shrink their ER according to need. An ER-localized monitoring system senses insufficient protein folding capacity and activates ER biogenesis to expand the organelle. Furthermore, cells dispose of excess or damaged ER by selective autophagy (ER-phagy). Together, these mechanisms ensure ER homeostasis and proper cell function.
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