Wie bakterielle Moleküle unser Immunsystem manipulieren
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Lipoproteins (Lpp) of Gram-positive bacteria play a crucial role in immune modulation. The degree of lipid acylation determines whether the TLR2/TLR1 or the TLR2/TLR6 signalling pathway is induced in the infected host. Both pathways differ significantly in the extent of innate immune activation. Commensal bacteria on our skin signal via the TLR2/TLR1 pathway thus inducing only a mild immune response while non-commensal bacteria signal via TLR2/TLR6 pathway thereby inducing a fulminant immune response. Consequently, the structure of the lipid residue in Lpp decides over immune tolerance or intolerance.
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- Nguyen MT, Uebele J, Kumari N et al. (2017) How commensal staphylococci adapt to our immune system. Nat Commun (accepted)Google Scholar