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BIOspektrum

, Volume 23, Issue 7, pp 759–761 | Cite as

Wie bakterielle Moleküle unser Immunsystem manipulieren

  • Minh Thu Nguyen
  • Friedrich Götz
Wissenschaft Lipoproteine

Abstract

Lipoproteins (Lpp) of Gram-positive bacteria play a crucial role in immune modulation. The degree of lipid acylation determines whether the TLR2/TLR1 or the TLR2/TLR6 signalling pathway is induced in the infected host. Both pathways differ significantly in the extent of innate immune activation. Commensal bacteria on our skin signal via the TLR2/TLR1 pathway thus inducing only a mild immune response while non-commensal bacteria signal via TLR2/TLR6 pathway thereby inducing a fulminant immune response. Consequently, the structure of the lipid residue in Lpp decides over immune tolerance or intolerance.

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Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2017

Authors and Affiliations

  1. 1.Mikrobielle Genetik, Interfakultäres Institut für Mikrobiologie und Infektionsmedizin Tübingen (IMIT)Universität TübingenTübingenDeutschland

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