BIOspektrum

, Volume 23, Issue 7, pp 752–755 | Cite as

Histonvarianten - Gleiche Gene bedeuten nicht gleiches Schicksal

Wissenschaft Epigenetik
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Abstract

Chromatin is one of the most significant structures to regulate gene expression. Active deposition and incorporation of specialized histone variants can lead to severe alterations in gene expression, cell cycle progression and embryonic development. Further, deregulation or mutations of histone variants are often implicated in diseases, most notably cancer development. Our work focuses on the discovery of novel human histone variants and variant-interactors to better understand fundamental epigenetic processes.

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Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2017

Authors and Affiliations

  1. 1.Abteilung für Molekularbiologie, Biomedizinisches CentrumLudwig-Maximilians-Universität MünchenPlanegg-MartinsriedDeutschland
  2. 2.Institut für Genetik, Fachbereich 08 - Biologie & ChemieJustus-Liebig-Universität GießenGießenDeutschland

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