Abstract
Chromatin is one of the most significant structures to regulate gene expression. Active deposition and incorporation of specialized histone variants can lead to severe alterations in gene expression, cell cycle progression and embryonic development. Further, deregulation or mutations of histone variants are often implicated in diseases, most notably cancer development. Our work focuses on the discovery of novel human histone variants and variant-interactors to better understand fundamental epigenetic processes.
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Ramona Spitzer 2008–2012 Bachelorstudium Molekulare Biotechnologie und 2012–2015 Masterstudium Biologie an der TU München. Seit 2015 Promotion in der Abteilung für Molekularbiologie an der LMU München.
Sandra Hake Biologiestudium an der RWTH Aachen und Promotion am Max-Planck-Institut für Immunbiologie, Freiburg. 2000–2003 Postdoc am Memorial-Sloan-Kettering Cancer Institute, New York, USA, und 2003–2006 an der Rockefeller University, New York. 2006–2016 Gruppenleiterin in der Abteilung für Molekularbiologie an der LMU München. Seit 2016 Profeßsorin (W3) für Genetik an der Universität Gießen.
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Spitzer, R.M.M., Hake, S.B. Histonvarianten - Gleiche Gene bedeuten nicht gleiches Schicksal. Biospektrum 23, 752–755 (2017). https://doi.org/10.1007/s12268-017-0865-6
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DOI: https://doi.org/10.1007/s12268-017-0865-6