Table 3 Event rates and multivariate Cox regression models for the composite endpoint POCE and the individual endpoints of POCE for both ICS ≥ 85 and ICS as a continuous covariate (ICS100 units). Values are n (cumulative incidence) unless specified otherwise. The multivariate model for POCE was stratified on diabetes due to non-proportional hazards. Detailed information and tables of full models can be found in Supplementary Table 2 (Electronic Supplementary Material)

From: The Prognostic Value of a Validated and Automated Intravascular Ultrasound-Derived Calcium Score

  Number of patients with event at 6-year follow-up ICS ≥ 85 ICS100 units
Event of interest Total (n=408) ICS < 85 (n=204) ICS ≥ 85 (n=204) HR (95% CI) p value HR (95% CI) p value
POCE 152 (44.4%) 61 (36.4%) 91 (51.8%) 1.51 (1.05–2.17) 0.026 1.21 (1.04–1.41) 0.014
Any revascularization 80 (23.2%) 37 (22.1%) 43 (24.2%) 1.31 (0.82–2.10) 0.26 1.23 (1.00–1.51) 0.055
PCI 71 (20.8%) 34 (20.4%) 37 (21.1%) 1.25 (0.77–2.05) 0.37 1.20 (0.96–1.49) 0.11
CABG 13 (3.6%) 5 (2.9%) 8 (4.3%) 1.61a (0.53–4.91) 0.41 1.30a (0.82–2.06) 0.27
Target vessel revascularization 42 (12.0%) 18 (10.4%) 24 (13.4%) 1.68 (0.88–3.19) 0.11 1.37 (1.06–1.77) 0.017
Any myocardial infarction 31 (9.3%) 12 (7.3%) 19 (11.0%) 1.44 (0.69–3.02) 0.33 1.28 (0.95–1.73) 0.10
Target vessel myocardial infarction 20 (5.7%) 8 (4.5%) 12 (6.7%) 1.47 (0.60–3.60) 0.40 1.29 (0.90–1.85) 0.17
Any stroke 14 (4.1%) 5 (2.9%) 9 (5.3%) 1.80a (0.60–5.38) 0.29 1.37a (0.89–2.10) 0.15
All-cause mortality 68 (18.9%) 21 (12.0%) 47 (25.6%) 1.55 (0.91–2.64) 0.10 1.16 (0.94–1.43) 0.17
  1. CABG coronary artery bypass graft, CI confidence interval, HR hazard ratio, ICS IVUS-calcium score, PCI percutaneous coronary intervention, POCE patient-oriented composite endpoint
  2. aDue to a limited number of events, only univariate cox regression could be provided