Table 3 Event rates and multivariate Cox regression models for the composite endpoint POCE and the individual endpoints of POCE for both ICS ≥ 85 and ICS as a continuous covariate (ICS100 units). Values are n (cumulative incidence) unless specified otherwise. The multivariate model for POCE was stratified on diabetes due to non-proportional hazards. Detailed information and tables of full models can be found in Supplementary Table 2 (Electronic Supplementary Material)
From: The Prognostic Value of a Validated and Automated Intravascular Ultrasound-Derived Calcium Score
| Number of patients with event at 6-year follow-up | ICS ≥ 85 | ICS100 units | |||||
|---|---|---|---|---|---|---|---|
| Event of interest | Total (n=408) | ICS < 85 (n=204) | ICS ≥ 85 (n=204) | HR (95% CI) | p value | HR (95% CI) | p value |
| POCE | 152 (44.4%) | 61 (36.4%) | 91 (51.8%) | 1.51 (1.05–2.17) | 0.026 | 1.21 (1.04–1.41) | 0.014 |
| Any revascularization | 80 (23.2%) | 37 (22.1%) | 43 (24.2%) | 1.31 (0.82–2.10) | 0.26 | 1.23 (1.00–1.51) | 0.055 |
| PCI | 71 (20.8%) | 34 (20.4%) | 37 (21.1%) | 1.25 (0.77–2.05) | 0.37 | 1.20 (0.96–1.49) | 0.11 |
| CABG | 13 (3.6%) | 5 (2.9%) | 8 (4.3%) | 1.61a (0.53–4.91) | 0.41 | 1.30a (0.82–2.06) | 0.27 |
| Target vessel revascularization | 42 (12.0%) | 18 (10.4%) | 24 (13.4%) | 1.68 (0.88–3.19) | 0.11 | 1.37 (1.06–1.77) | 0.017 |
| Any myocardial infarction | 31 (9.3%) | 12 (7.3%) | 19 (11.0%) | 1.44 (0.69–3.02) | 0.33 | 1.28 (0.95–1.73) | 0.10 |
| Target vessel myocardial infarction | 20 (5.7%) | 8 (4.5%) | 12 (6.7%) | 1.47 (0.60–3.60) | 0.40 | 1.29 (0.90–1.85) | 0.17 |
| Any stroke | 14 (4.1%) | 5 (2.9%) | 9 (5.3%) | 1.80a (0.60–5.38) | 0.29 | 1.37a (0.89–2.10) | 0.15 |
| All-cause mortality | 68 (18.9%) | 21 (12.0%) | 47 (25.6%) | 1.55 (0.91–2.64) | 0.10 | 1.16 (0.94–1.43) | 0.17 |