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Effects of Intra-aortic Balloon Pump Counterpulsation on Left Ventricular Mechanoenergetics in a Porcine Model of Acute Ischemic Heart Failure

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Abstract

We investigated the effects of intra-aortic balloon pump (IABP) counterpulsation on left ventricular (LV) contractility, relaxation, and energy consumption and probed the underlying physiologic mechanisms in 12 farm pigs, using an ischemia-reperfusion model of acute heart failure. During both ischemia and reperfusion, IABP support unloaded the LV, decreased LV energy consumption (pressure-volume area, stroke work), and concurrently improved LV mechanical performance (ejection fraction, stroke volume, cardiac output). During reperfusion exclusively, IABP also improved LV relaxation (tau) and contractility (Emax, PRSW). The beneficial effects of IABP support on LV relaxation and contractility correlated with IABP-induced augmentation of coronary blood flow. In conclusion, we find that during both ischemia and reperfusion, IABP support optimizes LV energetic performance (decreases energy consumption and concurrently improves mechanical performance) by LV unloading. During reperfusion exclusively, IABP support also improves LV contractility and active relaxation, possibly due to a synergistic effect of unloading and augmentation of coronary blood flow.

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Conflict of Interest

All authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. 3rd Department of Cardiology, Laiko Hospital, University of Athens School of Medicine, 67 Mikras Asias Street, 11 527, Athens, Greece

    Konstantinos Malliaras, Efstratios Charitos, Nikolaos Diakos, Iraklis Pozios, John Terrovitis & John Nanas

  2. Experimental-Research Center, Elpen Pharmaceuticals, Athens, Greece

    Apostolos Papalois

Authors
  1. Konstantinos Malliaras
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  2. Efstratios Charitos
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  3. Nikolaos Diakos
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  4. Iraklis Pozios
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  5. Apostolos Papalois
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  6. John Terrovitis
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  7. John Nanas
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Correspondence to Konstantinos Malliaras.

Additional information

Associate Editor Craig Stolen oversaw the review of this article

All institutional and national guidelines for the care and use of laboratory animals were followed and approved by the appropriate institutional committees. No human studies were carried out by the authors of this article.

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Malliaras, K., Charitos, E., Diakos, N. et al. Effects of Intra-aortic Balloon Pump Counterpulsation on Left Ventricular Mechanoenergetics in a Porcine Model of Acute Ischemic Heart Failure. J. of Cardiovasc. Trans. Res. 7, 810–820 (2014). https://doi.org/10.1007/s12265-014-9600-6

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  • DOI: https://doi.org/10.1007/s12265-014-9600-6

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