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Scientific Foundation and Possible Implications for Practice of the Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of AngioX (MATRIX) Trial

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Abstract

Early invasive management and the use of combined antithrombotic therapies have decreased the risk of recurrent ischaemia in patients with acute coronary syndrome (ACS) but have also increased the bleeding risk. Transradial intervention (TRI) and bivalirudin infusion compared to transfemoral intervention (TFI) or unfractionated heparin (UFH) plus glycoprotein IIb/IIIa inhibitors (GPI) decrease bleeding complications in patients with ACS. To what extent, a bleeding preventive strategy incorporating at least one of these two treatment options translates into improved outcomes is a matter of debate. The Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of AngioX study is a large-scale, multicenter, prospective, open-label trial, conducted at approximately 100 sites in Europe aiming to primarily assess whether TRI and bivalirudin infusion, as compared to TFI and UFH plus provisional GPI, decrease the 30-day incidence of death, myocardial infarction or stroke across the whole spectrum of ACS patients.

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Conflict of Interest

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Author information

Authors and Affiliations

  1. Thoraxcenter, Ba 587, Erasmus MC, Rotterdam, The Netherlands

    Marco Valgimigli

  2. Seconda Università di Napoli, A.O. dei Colli, Monaldi, Naples, Italy

    Paolo Calabrò

  3. Ospedale FatebeneFratelli, Milan, Italy

    Bernardo Cortese

  4. Cardiostudy, Eustrategy Association, Forlì, Forlì-Cesena, Italy

    Enrico Frigoli

  5. A.O. Ospedale Civile di Vimercate, Desio, Monza and Brianza, Italy

    Stefano Garducci

  6. Ospedale Villa Scassi, Genoa, Italy

    Paolo Rubartelli

  7. A.O. Universitaria G. Martino, Messina, Italy

    Giuseppe Andò

  8. Ospedali degli Infermi, Rimini, Italy

    Andrea Santarelli

  9. Azienda Ospedaliera Sant’Anna, Como, Italy

    Mario Galli

  10. San Giovanni Bosco Hospital, Turin, Italy

    Roberto Garbo

  11. Policlinico San Matteo, Pavia, Italy

    Alessandra Repetto

  12. Ospedale Sirai, Carbonia, Carbonia-Iglesias, Italy

    Salvatore Ierna

  13. Clinica Mediterranea, Naples, Italy

    Carlo Briguori

  14. Ospedale della Misericordia, Grosseto, Italy

    Ugo Limbruno

  15. A. O. San Camillo-Forlanini, Rome, Italy

    Roberto Violini

  16. Ospedale degli Infermi, Rivoli, Turin, Italy

    Andrea Gagnor

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on behalf of the MATRIX investigators

Corresponding author

Correspondence to Marco Valgimigli.

Additional information

Associate Editor Emanuele Barbato oversaw the review of this article.

The MATRIX trial is sponsored by the Gruppo Italiano Studi Emodinamica and EUSTRATEGY (co-sponsor), and it is conducted with support from The Medicines Company and Terumo.

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Valgimigli, M., Calabrò, P., Cortese, B. et al. Scientific Foundation and Possible Implications for Practice of the Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of AngioX (MATRIX) Trial. J. of Cardiovasc. Trans. Res. 7, 101–111 (2014). https://doi.org/10.1007/s12265-013-9537-1

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  • DOI: https://doi.org/10.1007/s12265-013-9537-1

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