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Lack of Association Between DNMT3B Polymorphisms and Sporadic Parkinson’s Disease in a Han Chinese Population

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References

  1. Sandor C, Honti F, Haerty W, Szewczyk-Krolikowski K, Tomlinson P, Evetts S, et al. Whole-exome sequencing of 228 patients with sporadic Parkinson’s disease. Sci Rep 2017, 7: 41188.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  2. Siitonen A, Nalls MA, Hernandez D, Gibbs JR, Ding J, Ylikotila P, et al. Genetics of early-onset Parkinson’s disease in Finland: exome sequencing and genome-wide association study. Neurobiol Aging 2017, 53: 195.e7–195.e10.

    Article  CAS  Google Scholar 

  3. Pezzi JC, de Bem CM, da Rocha TJ, Schumacher-Schuh AF, Chaves ML, Rieder CR, et al. Association between DNA methyltransferase gene polymorphism and Parkinson’s disease. Neurosci Lett 2017, 639: 146–150.

    Article  PubMed  CAS  Google Scholar 

  4. Chen X, Xiao Y, Wei L, Wu Y, Lu J, Guo W, et al. Association of DNMT3b gene variants with sporadic Parkinson’s disease in a Chinese Han population. J Gene Med 2017, 19: 360–365.

    PubMed  CAS  Google Scholar 

  5. Jowaed A, Schmitt I, Kaut O, Wullner U. Methylation regulates alpha-synuclein expression and is decreased in Parkinson’s disease patients’ brains. J Neurosci 2010, 30: 6355–6359.

    Article  PubMed  CAS  Google Scholar 

  6. Song Y, Ding H, Yang J, Lin Q, Xue J, Zhang Y, et al. Pyrosequencing analysis of SNCA methylation levels in leukocytes from Parkinson’s disease patients. Neurosci Lett 2014, 569: 85–88.

    Article  PubMed  CAS  Google Scholar 

  7. Tan YY, Wu L, Zhao ZB, Wang Y, Xiao Q, Liu J, et al. Methylation of alpha-synuclein and leucine-rich repeat kinase 2 in leukocyte DNA of Parkinson’s disease patients. Parkinsonism Relat Disord 2014, 20: 308–313.

    Article  PubMed  Google Scholar 

  8. Coppedè F, Bosco P, Tannorella P, Romano C, Antonucci I, Stuppia L, et al. DNMT3B promoter polymorphisms and maternal risk of birth of a child with Down syndrome. Hum Reprod 2013, 28: 545–550.

    Article  PubMed  CAS  Google Scholar 

  9. Xiao Y, Word B, Hammons G, Lyn-Cook B. Transcriptional activity of DNMT3B in pancreatic cancer cells: effects of -149 (C→T) promoter polymorphism. Biochem Biophys Res Commun 2011, 415: 220–223.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

We are grateful to the participants in this study. This work was supported by the National Natural Science Foundation of China (81430022, 91332107, and 81371407), and the National Key R&D Program of China (2016YFC1306000).

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Author notes

  1. Hong Pan and Jun-Yi Shen have contributed equally to this work.

Authors and Affiliations

  1. Laboratory of Neurodegenerative Diseases, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China

    Hong Pan

  2. Department of Neurology and Collaborative Innovation Center for Brain Science, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

    Hong Pan, Jun-Yi Shen, Juan-Juan Du, Shi-Shuang Cui, Jin Liu, Yi-Qi Lin, Yi-Xi He, Yang Fu, Chao Gao, Gen Li, Sheng-Di Chen & Jian-Fang Ma

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  1. Hong Pan
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Correspondence to Sheng-Di Chen or Jian-Fang Ma.

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Pan, H., Shen, JY., Du, JJ. et al. Lack of Association Between DNMT3B Polymorphisms and Sporadic Parkinson’s Disease in a Han Chinese Population. Neurosci. Bull. 34, 867–869 (2018). https://doi.org/10.1007/s12264-018-0233-7

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  • DOI: https://doi.org/10.1007/s12264-018-0233-7

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