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Neuroscience Bulletin

, Volume 34, Issue 3, pp 539–542 | Cite as

Up-Regulation of Akt and Nav1.8 in BmK I-Induced Pain

  • Guokun Zhou
  • Yunlu Jiao
  • You Zhou
  • Shichao Qin
  • Jie Tao
  • Feng Jiang
  • Zhi-Yong Tan
  • Yong-Hua Ji
Letter to the Editor
  • 123 Downloads

Dear Editor,

As the key contributor to the rising phase of action potentials in dorsal root ganglion (DRG) neurons, voltage-gated sodium channels (VGSCs) are important in physiological and pathological pain conditions. For instance, abnormal expression of VGSCs in DRG neurons is the main cause of the induction and maintenance of chronic inflammatory pain. Previously, we have reported that functional up-regulation of a peripheral VGSC isoform Nav1.8 is critical in pain behaviors induced by BmK I, a sodium channel activator purified from the venom of Buthus martensi Karsch (BmK) [1]. It is well known that protein kinase B/Akt participates in multiple cellular processes including protein synthesis, cell survival, proliferation, and metabolism. Moreover, it has been demonstrated that the Akt pathway plays an indispensable role in the hyperexcitability of peripheral sensory neurons and therefore contributes to the generation and maintenance of pathological pain [2, 3]. The activation of...

Notes

Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (31571032, 31771191, and 81402903). ZYT was supported by an Indiana Spinal Cord and Brain Injury Research Fund grant (ISCBIRF2017) from the Indiana State Department of Health.

Compliance with Ethical Standards

Conflict of interest

The authors declare that there are no competing interest.

Supplementary material

12264_2018_222_MOESM1_ESM.pdf (147 kb)
Supplementary material 1 (PDF 148 kb)

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Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Guokun Zhou
    • 1
  • Yunlu Jiao
    • 1
  • You Zhou
    • 1
  • Shichao Qin
    • 1
  • Jie Tao
    • 1
  • Feng Jiang
    • 2
  • Zhi-Yong Tan
    • 3
  • Yong-Hua Ji
    • 1
    • 2
  1. 1.Lab of Neuropharmacology and NeurotoxicologyShanghai UniversityShanghaiChina
  2. 2.Xinhua Translational Institute for Cancer PainShanghaiChina
  3. 3.Department of Pharmacology and Toxicology and Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisUSA

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