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Male Breast Cancer—an Indian Multicenter Series of 106 Cases

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Abstract

Male breast cancer (MBC) accounts for < 1% of all breast cancers. The available data on male breast cancer is mainly retrospective institution-based studies. Due to the scarcity of the disease, randomized controlled trials have not been feasible. Conducting a multicenter study is the next best option to assess the effectiveness of the treatment which is currently followed as per the guidelines on female breast cancer (FBC). Under the aegis of Delhi Breast Oncology Group (DBOG), data of 106 MBC patients was collected from 11 leading hospitals of Delhi and analyzed from January 2010 to April 2017. The age of the patients ranged from 35 to 82 years with a median of 59 years. The commonest presentation was a lump in the breast (98%). There was a delay in presentation of 1–6 months in the majority (86%) of cases. of the total number of patients, 51% had Stage II, 25% Stage III, 18% Stage I, 4% Stage 0, and 2% Stage IV breast cancer at the time of presentation. Infiltrating ductal carcinoma was the commonest histopathological finding. IHC receptor studies revealed ER positivity in 81% and PR positivity in 76%. HER2 neu positivity was seen in 25% of cases. Modified radical mastectomy was the commonest (92%) surgical procedure. Of the total number of cases, 18% received neoadjuvant chemotherapy, 35% received adjuvant chemotherapy, 32% underwent radiotherapy, and 74% received hormonal therapy. The 5-year cumulative disease-free survival was 60.7%. MBC is rare and unique. There are differences from FBC with respect to time of presentation, aggressiveness, histopathology, IHC markers, and response to treatment with a poorer outcome. Multicentric prospective studies are recommended for future research.

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Authors and Affiliations

  1. Deen Dayal Upadhyay Hospital, New Delhi, India

    M. K. Chhabra

  2. Vardhman Mahavir Medical College, Safdarjang Hospital, New Delhi, India

    Chintamani

  3. Breast Surgical Oncology, Max Institute of Cancer Care, Max Hospital, Patparganj and Vaishali, Delhi-NCR, India

    G. Kadyaprath

  4. Department of Surgical Disciplines, AIIMS, New Delhi, India

    A. Srivastva & P. Ranjan

  5. Breast Oncology, Max institute of cancer care Shalimar Bagh, New Delhi, India

    V. Selvakumar

  6. Department of Surgery, PGIMER RML Hospital, New Delhi, India

    C. K. Durga

  7. Department of Surgery, Lady Hardinge Medical College, New Delhi, India

    S. Thomas

  8. Department of Surgery, UCMS & GTB Hospital, New Delhi, India

    N. Kaur

  9. Department of Head, Neck and Breast Oncoplasty, Fortis Hospital Vasant Kunj, New Delhi, India

    M. Singh

  10. Department of Surgery, IGESI Hospital, Jhilmil, New Delhi, India

    M. Govil

  11. Acharya Shree Bhikshu Hospital, Moti Nagar, New Delhi, India

    A. Gupta

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  1. M. K. Chhabra
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  2. Chintamani
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Correspondence to M. K. Chhabra.

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Chhabra, M.K., Chintamani, Kadyaprath, G. et al. Male Breast Cancer—an Indian Multicenter Series of 106 Cases. Indian J Surg 83 (Suppl 2), 333–340 (2021). https://doi.org/10.1007/s12262-019-01953-w

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  • DOI: https://doi.org/10.1007/s12262-019-01953-w

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