Abstract
Our study was done to compare the results of frozen section (FS) with intraoperative fine needle aspiration cytology (FNAC), imprint cytology (IC) and permanent paraffin embedded histopathological sections in determining tumour margin and to find out an alternative, rapid, simple and cost-effective method in determining the tumour margin in a setup where frozen section facility is not available. Intraoperative FNAC and imprint cytology were collected from 42 patients with malignant neoplasm. Frozen section was also done on the tissue collected from those patients. These findings were also compared with permanent paraffin embedded histopathological sections. Sensitivities of both imprint cytology and frozen section study were similar and specificity was 100% for FNAC, IC and FS study. Thus, we can use FNAC and imprint cytology together to determine tumour margin over much expensive and laborious frozen section study and also where frozen section facilities are not available.
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Abbreviations
- FNAC:
-
Fine needle aspiration cytology
- TIC:
-
Touch imprint cytology
- FS:
-
Frozen section
- PPV:
-
Positive predictive value
- NPV:
-
Negative predictive value
- IOTPC:
-
Intraoperative touch preparation cytology
References
Haeri H, Djamali M (2002) Comparison of the cytology technique and the frozen section results in intraoperative consultation of the breast lesions. Acta Medica Iranica 40:203–206
Ranchod M (2010) Intraoperative Consultation in Surgical Pathology. Weiss, L, Ranchod, M (eds). Cambridge University Press, p3
Olson SM, Hussaini M, Lewis JS Jr. (2011) Frozen section analysis of margins for head and neck tumor resections: reduction of sampling errors with a third histologic level. Mod Pathol 24:665–670
Scholl P, Byers RM, Batsakis JG, Wolf P, Santini H (1986) Microscopic cut through of cancer in the surgical treatment of squamous carcinoma of the tongue. Prognostic and therapeutic implications. Am J Surg 152:354–360
Kaufman Z et al (1986) Frozen-section diagnosis in surgical pathology. A prospective analysis of 526 frozen sections. Cancer 57:377–379
Ku NN, Cox CE, Reintgen DS, Greenberg HM, Nicosia SV (1991) Cytology of lumpectomy specimens. Acta Cytol 35:417–421
D'Andrea V, Redler A, Calò P et al (2000) Thyroid nodules: comparison of preoperative and intraoperative needle aspirate and definite histological study. Chir Ital 52(2):147–153
DiMusto JC (1970) Reliability of frozen sections in gynaecologic surgery. Obstet Gynecol 35:235
Olson TP, Harter J, Munoz A, Mahvi DM, Breslin T (2007) Frozen section analysis for intraoperative margin assessment during breast-conserving surgery results in low rates of re-excision and local recurrence. Ann Surg Oncol 14:2953–2960
Coffey D, Kaplan AL, Ramzy I (2005) Intraoperative consultation in gynecologic pathology. Arch Pathol Lab Med 129:1544–1557
Tribe CR (1965) Cytological diagnosis of breast tumors by the imprint method. J Clin Pathol 18:31–39
Esbona K, Li Z, Wilke LG (2012) Intraoperative imprint cytology and frozen section pathology for margin assessment in breast conservation surgery: a systematic review. Ann Surg Oncol 19(10):3236–3245
Creager AJ, Shaw JA, Young PR, Geisinger KR (2002) Intraoperative evaluation of lumpectomy margins by imprint cytology with histologic correlation: a community hospital experience. Arch Pathol Lab Med 126:846–848
Valdes EK, Boolbol SK, Ali I et al (2007) Intraoperative touch preparation cytology for margin assessment in breast-conservation surgery: does it work for lobular carcinoma? Ann Surg Oncol 14:2940–2945
Klimberg VS, Westbrook KC, Korourian S (1998) Use of touch preps for diagnosis and evaluation of surgical margins in breast cancer. Ann Surg Oncol 5:220–226
Weinberg E, Cox C, Dupont E et al (2004) Local recurrence in lumpectomy patients after imprint cytology margin evaluation. Am J Surg 188:349–354
Buley ID, Roskell DE (2000) Fine needle aspiration cytology in tumour diagnosis: uses and limitations. Clin Oncol 12:166–171
Rekhi B, Gorad BD, Kakade AC, Chinoy RF (2007) Scope of FNAC in the diagnosis of soft tissue tumors-a study from a tertiary cancer referral centre in India. CytoJournal 4:20
Krishnamurthy SC, Soni M, Jagannath KS, DeSouza LJ (1993) Intraoperative fine needle aspiration cytology of pancreas: a study of 97 cases. Indian J Gastroenterol 12(1):14–15
Saez A, Catala I, Brossa R, Funes A, Jaurrieta E, Ferrer JE (1995) Intraoperative fine needle aspiration cytology of pancreatic lesions. A study of 90 cases. Acta Cytol 39(3):485–488
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Mondal, R., Koley, S. & Biswas, P.K. Comparative Study Between Intraoperative Fine Needle Aspiration Cytology/Imprint Cytology and Frozen Section in Determination of Tumour Margin. Indian J Surg 80, 554–558 (2018). https://doi.org/10.1007/s12262-017-1661-8
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DOI: https://doi.org/10.1007/s12262-017-1661-8