Skip to main content

Advertisement

SpringerLink
Log in

Incidental Findings in Routine Histopathological Examination of Appendectomy Specimens; Retrospective Analysis of 1970 Patients

  • Original Article
  • Published:
Indian Journal of Surgery Aims and scope Submit manuscript

Abstract

Diseases and tumors of the appendix vermiformis are very rare, except for acute appendicitis. This study aimed to examine rare findings in the histopathologic examinations of specimens of patients undergoing appendectomy due to the diagnosis of acute appendicitis. The files of 1970 patients undergoing appendectomy due to the diagnosis of acute appendicitis between March 2012 and March 2016 were retrospectively investigated. Rare findings were found in 59 (3 %) patients, and these were evaluated in detail. Patients’ age, gender, pathology reports, and postoperation follow-ups were recorded. The rare histopathological findings of 59 patients were examined. Of these, 31 were female (52.5 %) and 28 were male (47.5 %). The average age was 33.1 ± 18.2 years. The unusual findings were as follows: 16 fibrous obliteration, 11 Enterobius vermicularis, 2 schistosomiasis, 3 appendiceal neuroma, 2 granulomatous appendicitis, 1 Crohn’s disease, 3 chronic appendicitis, 1 endometriosis, 2 hyperplastic polyps, 9 mucinous cystadenoma (+mucocele), 8 carcinoid tumors, and 1 lymphoma. All of the malignant tumors were localized in the distal end of the appendix, and all of the patients were treated with appendectomy. Patients with parasitic diseases also underwent anthelmintic treatment, while chemotherapy was administered to the patient with lymphoma. All of the patients diagnosed with malignancy were alive reported no problems at their follow-ups. Although all of the appendectomy samples were normal macroscopically, data from this study suggest that all specimens should be sent for routine investigation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Flum DR, Koepsell T (2002) The clinical and economic correlates of misdiagnosed appendicitis: nationwide analysis. Arch Surg 137(7):799–804

    Article  PubMed  Google Scholar 

  2. Akbulut S, Tas M, Sogutcu N, Arikanoglu Z, Basbug M, Ulku A, Semur H, Yagmur Y (2011) Unusual histopathological findings in appendectomy specimens: a retrospective analysis and literature review. World J Gastroenterol 17(15):1961–1970

    Article  PubMed  PubMed Central  Google Scholar 

  3. Emre A, Akbulut S, Bozdag Z, Yilmaz M, Kanlioz M, Emre R et al (2013) Routine histopathologic examination of appendectomy specimens: retrospective analysis of 1255 patients. Int Surg 98(4):354–362

    Article  PubMed  PubMed Central  Google Scholar 

  4. Matthyssens LE, Ziol M, Barrat C, Champault GG (2006) Routine surgical pathology in general surgery. Br J Surg 93(3):362–368

    Article  CAS  PubMed  Google Scholar 

  5. The Royal College of Pathologists 2005 Histopathology and Cytopathology of limited or no clinical value 2nd edition. London. [http://www.rcpath.org/publications]

  6. Chan W, Fu KH (1987) Value of routine histopathological examination of appendices in Hong Kong. J Clin Pathol 40(4):429–433

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Nemeth L, Reen DJ, O’Briain D, McDermott M, Pui P (2001) Evidence of an inflammatory pathologic condition in “normal” appendices following emergency appendectomy. Arch Path Lab Med 125(6):759–764

    CAS  PubMed  Google Scholar 

  8. Connor SJ, Hanna GB, Frizell FA (1998) Appendiceal tumors. Dis Colon rectum 41(1):75–80

  9. Kozar RA, Roslyn JJ (1999) The appendix. In: Schwartz SI (ed) Principles of surgery. McGraw-Hill, New York

    Google Scholar 

  10. Russell RC, Williams NS, Bulstrode CJ (2000) The vermiform appendix. In: Russell RC, Williams NS, Bulstrode CJ (eds) Bailey and Love’s short practice of surgery, 23 th edn. Arnold Publishers, London, pp. 1076–1092

    Google Scholar 

  11. Duzgun AP, Moran M, Uzun S, Ozmen MM, Ozer VM, Seckin S, Coskun F (2004) Unusual findings in appendicectomy specimens: evaluation of 2458 cases and review of the literature. Indian J Surg 66(4):221–226

    Google Scholar 

  12. Jones AE, Phillips AW, Jarvis JR, Sargen K (2007) The value of routine histopathological examination of appendicectomy specimens. BMC Surg 7:17

    Article  PubMed  PubMed Central  Google Scholar 

  13. Chamisa I (2009) A clinicopathological review of 324 appendices removed for acute appendicitis in Durban, South Africa: a retrospective analysis. Ann R Coll Surg Engl 91(8):688–692

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Yabanoglu H, Caliskan K, Ozgur Aytac H, Turk E, Karagulle E, Kayaselcuk F et al (2014) Unusual findings in appendectomy specimens of adults: retrospective analyses of 1466 patients and a review of literature. Iran Red Crescent Med J 16(2):1–6

    Article  Google Scholar 

  15. Ladu R (2014) Schistosomiasis as a rare cause of recurrent acute appendicitis: a case report. Int J Surg Case Report 5(3):159–160

    Article  Google Scholar 

  16. Steinmann P, Keiser J, Boss R, Tanner M, Utzinger J (2006) Schistosomiasis and water resources development: systemic review, meta-analysis and estimates of people at risk. Lancet Infect Dis 6(7):411–425

    Article  PubMed  Google Scholar 

  17. Gali BM, Nggada HA (2006) Schistosomiasis of the appendix in Maiduguri. Trop Doctor 36(3):162–163

    Article  CAS  Google Scholar 

  18. Gupta K, Solanki A, Vasishta RK (2011) Appendiceal neuroma: report of an elusive neuroma. Trop Gastroenterol 32(4):332–333

    PubMed  Google Scholar 

  19. Patel AV, Friedman M, MacDermott RP (2010) Crohn’s disease patient with right lower quadrant abdominal pain for 20 years due to an appendiceal neuroma (fibrous obliteration of the appendix). Inflamm Bowel Dis 16(7):1093–1094

    Article  PubMed  Google Scholar 

  20. AbdullGaffar B (2010) Granulomatous diseases and granulomas of the appendix. Int J Surg Pathol 18(1):14–20

    Article  PubMed  Google Scholar 

  21. Tucker ON, Healy V, Jeffers M, Keane FB (2003) Granulomatous appendicitis. Surgeon 1(5):286–289

    Article  CAS  PubMed  Google Scholar 

  22. Shivakumar P, Shanmugam RP, Mani CS (2010) Idiopathic granulomatous appendicitis: a rare appendicular pseudo tumor. Trop Gastroenterol 31(2):130–131

    CAS  PubMed  Google Scholar 

  23. Shapiro R, Eldar S, Sadot E, Papa MZ, Zippel DB (2011) Appendiceal carcinoid at a large tertiary center: pathologic findings and long-term follow-up evaluation. Am J Surg 201(6):805–808

    Article  PubMed  Google Scholar 

  24. In’t Hof KH, van der Wal HC, Kazemier G, Lange JF (2008) Carcinoid tumour of the appendix: an analysis of 1,485 consecutive emergency appendectomies. J Gastrointest Surg 12(8):1436–1438

    Article  PubMed  PubMed Central  Google Scholar 

  25. Demetrashvili Z, Chkhaidze M, Khutsishvili K, Topchishvili G, Javakhishvili T, Pipia I (2012) Mucocele of the appendix: case report and review of literature. Int Surg 97(3):266–269

    Article  PubMed  PubMed Central  Google Scholar 

  26. Limaiem F, Bouraoui S, Bouahmed S, Sahraoui G, Lahmar A, Mzabi-Regaya S (2015) Appendiceal hyperplastic polyp: case report. J Interdiscipl Histopathol 3(1):36–38

    Article  Google Scholar 

  27. Kothadia JP, Katz S, Ginzburg L (2015) Chronic appendicitis: uncommon cause of chronic abdominal pain. Therap Adv Gastroenterol 8(3):160–162

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of General Surgery, Faculty of Medicine, Adiyaman University, Yeni mah. 26294 sk. Elif Kent Sitesi B Blok No:2, Adiyaman, Turkey

    Oğuzhan Dincel & Mustafa Göksu

  2. Department of Pathology, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey

    Bilge Aydın Türk, Burçin Pehlivanoğlu & Serap İşler

Authors
  1. Oğuzhan Dincel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mustafa Göksu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bilge Aydın Türk
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Burçin Pehlivanoğlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Serap İşler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Oğuzhan Dincel.

Ethics declarations

This study was approved by the local ethics committee.

Conflict of Interest

The authors declare that they have no conflict of interest.

Informed Consent

Written informed consent was obtained from the patient.

Funding

The authors declared that this case has received no financial support.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dincel, O., Göksu, M., Türk, B.A. et al. Incidental Findings in Routine Histopathological Examination of Appendectomy Specimens; Retrospective Analysis of 1970 Patients. Indian J Surg 80, 48–53 (2018). https://doi.org/10.1007/s12262-016-1557-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12262-016-1557-z

Keywords

Search

Navigation