Aim of this study was to select all the cases of Primary (PBL) and Secondary (SBL) Breast Lymphoma from our breast unit since 01/01/2000, to obtain up-to-date data on the prevalence of this rare pathology and to analyze imaging features, with a special focus on CT. All pathological reports of breast biopsies performed from 01/01/2000 to 01/01/2019 were at first screened. Among them, we performed two different researches, looking for key words suggesting either a diagnosis of lymphoma or any other malignant disease. Using the Wiseman criteria, we identify PBL and SBL. All imaging features of PBL and SBL were analyzed. Prevalence of lymphoma amongst suspicious breast masses and amongst all breast malignancies were calculated. Out of 42,505 histopathology reports from mammary nodule biopsies, we found 19,354 malignancies. We were able to identify 11 patients affected by PBL (0,03% of suspicious breast lesions, 0.06% of breast malignancies), and 23 cases of SBL (0,05% of suspicious breast lesions, 0,12% of breast malignancies). Most common isotype in PBL was DLBC lymphoma, whereas in SBL that resulted Follicular lymphoma. In PBL group, we were able to retrieve images 7 CT or CT-PET study performed at diagnosis 7 US, 1 mammography and and 1 MR. In SBL group, we analyzed 14 CT/CT-PET examinations, 11 US studies and 3 mammography. PBL and SBL are rarer than considered until now. There is no definite imaging characteristic able to distinguish between these two pathologies and among them and breast cancer.
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Sabaté JM, Gómez A, Torrubia S et al (2002) Lymphoma of the breast: clinical and radiologic features with pathologic correlation in 28 patients. Breast J 8:294–304
Wiseman C, Liao K (1972) Primary lymphoma of the breast. Cancer 29:1705–1712
Hugh JC, Jackson F, Hanson J, Poppema S (1990) Primary breast lymphoma. An immunohistologic study of 20 new cases. Cancer 66:2602–2611
Avenia N, Sanguinetti A, Cirocchi R, Bistoni G, Trastulli S, D'Ajello F, Barberini F, Cavallaro G, Rulli A, Sidoni A, Noya G, de Toma G, Sciannameo F (2010) Primary breast lymphomas: a multi- centric experience. World J Surg Oncol 8:53
Giardini R, Piccolo C, Rilke F. Primary non-Hodgkin's lymphomas of the female breast. Cancer 1992;69:725±35, 735
Mattia AR, Ferry JA, Harris NL (1993) Breast lymphoma: a B-cell spectrum including low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. Am J Surg Pathol 17:574–587
Brogi E, Harris NL (1999) Lymphomas of the breast: pathology and clinical behavior. Semin Oncol 26:357–364
Topalovski M, Cristan D, Mattson JC (1999) Lymphoma of the breast: a clinicopathologic study of primary and secondary cases. Arch Pathol Lab Med 123:1208–1218
Freeman C, Berg JW, Cutler SJ (1972) Occurrence and prognosis of extranodal lymphomas. Cancer 29:252–260
Yhim HY, Kang HJ, Choi YH, Kim SJ, Kim WS, Chae YS, Kim JS, Choi CW, Oh SY, Eom HS, Kim JA, Lee JH, Won JH, Shim H, Lee JJ, Sung HJ, Kim HJ, Lee DH, Suh C, Kwak JY (2010) Clinical outcomes and prognostic factors in patients with breast diffuse large B cell lymphoma: consortium for improving survival of lymphoma (CISL) study. BMC Cancer 10:321
Franco Pérez F, Lavernia J et al (2016) Primary breast lymphoma: analysis of 55 cases of the Spanish lymphoma oncology group. Clinical Lymphoma, Myeloma & Leukemia 17(3):186–191
Cheah CY, Campbell B, Seymour J (2014) Primary breast lymphoma. Cancer Treat Rev 40:900–908
Aviv A, Tadmor T, Polliack A (2013) Primary diffuse large B-cell lymphoma of the breast: looking at pathogenesis, clinical issues and therapeutic options. Ann Oncol 24:2236–2244
Caon J, Wai E, Hart J et al (2012) Treatment and outcomes of primary breast lymphoma. Clin Breast Cancer 12:412–419
Surov A, Holzhausen H-J, Wienke A, Schmidt J, Thomssen C, Arnold D, Ruschke K, Spielmann R-P (2012) Primary and secondary breast lymphoma: prevalence, clinical signs and radiological features. Br J Radiol 85:e195–e205
Validire P, Capovilla C, Asselain B et al (2009) Primary breast non-Hodgkin’s lymphoma: a large single center study of initial characteristics, natural history, and prognostic factors. Am J Hematol 84:133–139
Jeanneret-Sozzi W, Taghian A, Epelbaum R (2008) Primary breast lymphoma: patient profile, outcome and prognostic factors. A multicentre rare cancer network study. BMC Cancer 8:86–92
Liu FF, Clark RM (1986) Primary lymphoma of the breast. Clin Radiol 37:567–570
Yang WT, Lane DL, LePetross HT, Abruzzo LV, Macapinlac HA (2007) Breast lymphoma: imaging findings of 32 tumors in 27 patients. Radiology 245:692–702
Balu-Maestro C, Bruneton JN, Rogopoulos A, Marcy PY, Guidicelli T, Raffaelli C et al (1992) Mammographic and ultrasonographic appearances of lymphoma of the breast. Eur Radiol 2:565–569
Liberman L, Giess CS, Dershaw DD, Louie DC, Deutch BM (1994) Non-Hodgkin lymphoma of the breast: imaging characteristics and correlation with histopathologic findings. Radio- logy 192:157–160
Surov A, Holzhausen HJ, Wienke A, Schmidt J, Thomssen C, Arnold D, Ruschke K, Spielmann RP (2012) Primary and secondary breast lymphoma: prevalence, clinical signs and radiological features. Br J Radiol 85:e195–e205
Jernstrom P, Sether JM (1967) Primary lymphosarcoma of the mammary gland. JAMA 201:503–506
Inoue M, Sano R, Watal R et al (2003) Dynamic multi- detector CT of breast tumors: diagnostic features and comparison with conventional techniques. AJR Am J Roentgenol 181:679–686
Harvey JA, Mahoney MC, Newell MS, Bailey L, Barke LD, D’Orsi C, Hayes MK, Jokich PM, Lee SJ, Lehman CD, Mainiero MB, Mankoff DA, Patel SB, Reynolds HE, Sutherland ML, Haffty BG (2013) ACR appropriateness criteria palpable breast masses. J Am Coll Radiol 10:742–749
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Picasso, R., Tagliafico, A., Calabrese, M. et al. Primary and Secondary Breast Lymphoma: Focus on Epidemiology and Imaging Features. Pathol. Oncol. Res. 26, 1483–1488 (2020). https://doi.org/10.1007/s12253-019-00730-0