Nuclear Cytoplasmic Inclusions in Lung Adenocarcinoma: Relevance of Immunohistochemistry

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Fig. 1


  1. 1.

    Kobayashi S, Saio M, Fukuda T et al (2019) Image analysis of the nuclear characteristics of emerin protein and the correlation with nuclear grooves and intranuclear cytoplasmic inclusions in lung adenocarcinoma. Oncol Rep 41:133 142

    PubMed  Google Scholar 

  2. 2.

    Rosai J (2011) Rosai and Ackman’s Surgical Pathology. 10th edition expert consult. Mosby Elsevier, Philadelphia

    Google Scholar 

  3. 3.

    Torikata C, Ishiwata K (1977) Intranuclear tubular structures observed in the cells of an alveolar cell carcinoma of the lung. Cancer 40:1194 1201

    Article  Google Scholar 

  4. 4.

    Gyorkey F, Gyorkey P, Sinkovics JG (1980) Origin and significance of intranuclear tubular inclusions in type II pulmonary alveolar epithelial cells of patients with bleomycin and busulfan toxicity. Ultrastruct Pathol 1:211 221

    Article  Google Scholar 

  5. 5.

    Singh G, Katyal SL, Torikata C (1982) Carcinoma of type II pneumocytes. PAS staining as a screening test for nuclear inclusions of surfactant specific apoprotein. Cancer 50:946 948

    Article  Google Scholar 

  6. 6.

    Mizutani Y, Nakajima T, Morinaga S et al (1988) Immunohistochemical localization of pulmonary surfactant apoproteins in various lung tumors. Special reference to nonmucus producing lung adenocarcinomas. Cancer 61:532 537

    Article  Google Scholar 

  7. 7.

    Knuhtsen H, Hiebert E, Purcifull DE (1974) Partial purification and some properties of tobacco etch virus induced intranuclear inclusions. Virology 61:200 209

    Article  Google Scholar 

  8. 8.

    Schwertheim S, Westerwick D, Jastrow H, Theurer S, Schaefer CM, Kälsch J, Möllmann D, Schlattjan M, Wedemeyer H, Schmid KW, Baba HA (2019) Intranuclear inclusions in hepatocellular carcinoma contain autophagy-associated proteins and correlate with prolonged survival. J Pathol Clin Res 5:164 176

  9. 9.

    Aida S, Shimazaki H, Sato K et al (2001) Prognostic significance of frequent acidophilic nuclear inclusions in adenocarcinoma of the lung with immunohistochemical and ultrastructural studies. Cancer 91:1896 1904

    Article  Google Scholar 

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Correspondence to Handra-Luca Adriana.

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Adriana, H. Nuclear Cytoplasmic Inclusions in Lung Adenocarcinoma: Relevance of Immunohistochemistry. Pathol. Oncol. Res. 26, 1989–1990 (2020).

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