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Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma

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Pathology & Oncology Research

Abstract

Cyclooxygenase-2 (COX-2) plays an important role in carcinogenesis, which catalyzes the conversion of arachidonic acid into prostaglandins. P53 is a tumor suppressor gene that contributes to apoptosis and cell cycle control. There is functional interaction between p53 and COX-2, which lead to abrogation of apoptosis and progression of malignancy. To assess the relationship between COX-2, p53 expression and the clinicopathololgic features in SLL and DLBCL. We immunohistochemically examined the expression of COX-2 and p53 in non-neoplastic lymphoid cells, lymph nodal low-grade (50 cases of SLL), intermediate and high-grade lymphomas (100 cases of DLBCL) and their corresponding bone marrow specimens. The expression of COX-2 and p53 was absent in the in non-neoplastic lymphoid cells. In contrast, their expression values increased progressively with the advancing grade of lymphoma (p < 0.001). COX-2 expression was significantly associated with advanced disease stage, high-grade lymphomas, and disease relapse and p53 expression. The p53was detected in 64.5% in patients positive for COX-2. The expressions of COX-2 and p53 proteins, were significantly associated with shorter overall-survival and progression free survival. Here we report up-regulation of COX-2and p53 protein expression in SLL and DLBCL indicating their interactive involvement in the pathogenesis of lymphoma. Our data provide a rationale for further investigation of COX-2 expression in lymphomas for potential prognostic, chemopreventive and chemotherapeutic purposes.

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Authors and Affiliations

  1. Medical Oncology & Hematology Department, South Egypt Cancer Institute, Asyut University, Assiut, Egypt

    Amen H. Zaky

  2. Pathology Department, Faculty of Medicine, Asyut University, Assiut, Egypt

    Dalia Elsers & Mahmoud Rezk

  3. Clinical Pathology Department, South Egypt Cancer Institute, Asyut University, Assiut, Egypt

    Rania Bakry

  4. Radiotherapy Department, South Egypt Cancer Institute, Asyut University, Assiut, Egypt

    Mostafa Abdelwanis

  5. Clinical Oncology Department, Asyut University, Assiut, Egypt

    Ola Nabih

  6. Internal Medicine, Hematology Unit, Asyut University, Assiut, Egypt

    Rania Hafez

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  1. Amen H. Zaky
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  2. Dalia Elsers
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Zaky, A.H., Elsers, D., Bakry, R. et al. Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma. Pathol. Oncol. Res. 26, 1183–1190 (2020). https://doi.org/10.1007/s12253-019-00674-5

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