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Genetic Variations of DNA Repair Genes in Breast Cancer

  • Original Article
  • Published:
Pathology & Oncology Research

Abstract

Genetic variations in DNA repair genes may affect DNA repair capacity therefore increase risk for cancer. In our study, we evaluted the relation between DNA repair gene polymorphisms XRCC1 rs1799782, rs25487, rs25489; XPC rs2228000, rs2228001; XPD rs1799793, rs13181; XRCC3 rs861539; RAD51B rs10483813, rs1314913 and breast cancer risk for 202 Turkish cases in total, in which 102 patients with breast cancer and 100 controls. Genotyping of the DNA samples was carried out by multiplex PCR and matrix-assisted laser desorption/ionization mass spectrometry with time of flight measurement (MALDI-TOF) using Sequenom MassARRAY 4 analyzer. Genotype and allele distributions were calculated between the groups. Odds ratios (ORs) and 95% confidence intervals (CIs) were reported. rs25487 AA genotype and A allele was found to be increased in the control group (respectively, OR 0.16 95% CI 0.02–1.06, p = 0.058; OR 1.55, 95% CI 1.01–2.36, p = 0.043) and rs861539 T allele was found to be decreased in the patient group (OR 1.53, 95% CI 1.01–2.30, p = 0.049). No association with breast cancer was found for the remaining SNPs. Our findings suggest that XRCC1 rs25487 AA genotype and A allele, XRCC3 rs861539 T allele may have protective effects in breast cancer for Turkish population.

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Acknowledgments

This study was supported by the Kastamonu University Scientific Research Projects Coordination Unit with the project number KÜBAP-01/2013-03. We thank very much to Assoc. Prof. Dr. Ergin Murat ALTUNER for language editing of the manuscript.

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Authors and Affiliations

  1. Kastamonu School of Medicine, Department of Medical Genetics, Kastamonu University, Kuzeykent Mah, Orgeneral Atilla Ateş Paşa Cd. No: 19 C, 37200, Kastamonu, Turkey

    Asuman Özgöz

  2. School of Medicine, Department of Medical Genetics, Süleyman Demirel University, Isparta, Turkey

    Kuyaş Hekimler Öztürk

  3. Fazıl Boyner Faculty of Health Sciences, Department of Nutrition and Dietetics, Kastamonu University, Kastamonu, Turkey

    Ayşegül Yükseltürk

  4. School of Veterinary Medicine, Department of Genetics, Uludag University, Bursa, Turkey

    Hale Şamlı

  5. School of Medicine, Department of Medical Oncology, Acıbadem University, Istanbul, Turkey

    Zuhal Başkan

  6. School of Medicine, Department of Medical Genetics, Giresun University, Giresun, Turkey

    Fadime Mutlu İçduygu

  7. Alanya Çıplaklı Family Health Center, Alanya-Antalya, Turkey

    Mehmet Bacaksız

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  1. Asuman Özgöz
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  2. Kuyaş Hekimler Öztürk
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  3. Ayşegül Yükseltürk
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  4. Hale Şamlı
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  5. Zuhal Başkan
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Corresponding author

Correspondence to Asuman Özgöz.

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Human Blood samples used in the study were obtained using protocols approved by the Acıbadem University Medical Research Assessment Committee. The written informed consent was taken from all the cases participated in the study.

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The authors declare that they have no conflict of interest.

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Özgöz, A., Hekimler Öztürk, K., Yükseltürk, A. et al. Genetic Variations of DNA Repair Genes in Breast Cancer. Pathol. Oncol. Res. 25, 107–114 (2019). https://doi.org/10.1007/s12253-017-0322-3

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  • DOI: https://doi.org/10.1007/s12253-017-0322-3

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