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Pathology & Oncology Research

, Volume 24, Issue 3, pp 447–456 | Cite as

The Tumor Entity Denominated “clear cell-papillary renal cell carcinoma” According to the WHO 2016 new Classification, have the Clinical Characters of a Renal Cell Adenoma as does Harbor a Benign Outcome

  • Francesco Massari
  • Chiara Ciccarese
  • Ondrej Hes
  • Michal Michal
  • Anna Caliò
  • Michelangelo Fiorentino
  • Francesca Giunchi
  • Alessandro D’Amuri
  • Francesca Sanguedolce
  • Roberto Sabbatini
  • Annalisa Guida
  • Andrea Ardizzoni
  • Camillo Porta
  • Roberto Iacovelli
  • Giampaolo Tortora
  • Luca Cima
  • Cinzia Ortega
  • Alberto Lapini
  • Guido Martignoni
  • Matteo BrunelliEmail author
Review

Abstract

The new WHO 2016 classification of renal neoplasia encounters the new entity called “clear cell papillary renal cell carcinoma” (ccpRCC). The ccpRCC has been long included as a subtype of clear cell RCC histotype and it actually ranges from 2 to 9% in different routinely available cohort of renal carcinomas. Of important note, ccpRCC does not show any recurrences or metastases or lymph-node invasion and the outcome is always good. We reviewed twenty-four publications with available follow-up for patients (no. 362) affected by clear cell papillary RCCs/renal adenomatoid tumours and notably ccpRCC harbors an indolent clinical behavior after a mean of 38 months (3,5 years) of follow-up. This paper reviews the histological, molecular and clinical features characterizing ccpRCC, with the goal of focusing the knowledge of the benign fashion of this new tumour entity, supporting the idea of a new renal cell adenoma recruited morphologically from ex conventional clear cell RCC tumours.

Keywords

Clear cell papillary RCC Renal adenomatoid tumour (RAT) WHO 2016 classification of renal neoplasia Renal adenoma Benign 

Notes

Acknowledgements

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Arányi Lajos Foundation 2017

Authors and Affiliations

  • Francesco Massari
    • 1
  • Chiara Ciccarese
    • 2
  • Ondrej Hes
    • 3
  • Michal Michal
    • 3
  • Anna Caliò
    • 4
  • Michelangelo Fiorentino
    • 5
  • Francesca Giunchi
    • 5
  • Alessandro D’Amuri
    • 6
  • Francesca Sanguedolce
    • 7
  • Roberto Sabbatini
    • 8
  • Annalisa Guida
    • 8
  • Andrea Ardizzoni
    • 1
  • Camillo Porta
    • 9
  • Roberto Iacovelli
    • 2
  • Giampaolo Tortora
    • 2
  • Luca Cima
    • 4
  • Cinzia Ortega
    • 10
  • Alberto Lapini
    • 11
  • Guido Martignoni
    • 4
    • 12
  • Matteo Brunelli
    • 4
    Email author
  1. 1.Division of OncologyS.Orsola-Malpighi HospitalBolognaItaly
  2. 2.Division of OncologyAOUI, University of VeronaVeronaItaly
  3. 3.Department of Pathology, Faculty of Medicine in PlzenCharles UniversityPilsenCzech Republic
  4. 4.Department of Diagnostics and Public HealthAOUI, University of VeronaVeronaItaly
  5. 5.Department of PathologyS.Orsola-Malpighi HospitalBolognaItaly
  6. 6.Anatomic PathologyCard. G. Panico HospitalLecceItaly
  7. 7.Department of PathologyUniversity of FoggiaFoggiaItaly
  8. 8.Department of Oncology, Hematology & Respiratory DiseasesUniversity of Modena & Reggio EmiliaModenaItaly
  9. 9.Division of OncologyI.R.C.C.S. San Matteo University Hospital FoundationPaviaItaly
  10. 10.Division of OncologyInstitute for Cancer Research and TreatmentBraItaly
  11. 11.Urology ClinicCarreggi Hospital, University of FlorenceFlorenceItaly
  12. 12.Anatomic PathologyPederzoli HospitalVeronaItaly

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