Genomic Characterization of a Novel Hepatovirus from Great Roundleaf Bats in China
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The hepatitis A virus (HAV) is a common agent causing acute liver disease worldwide, with approximately 11,000 deaths annually (WHO 2017). The virus is transmitted primarily by the fecal-oral route and it normally infects people living in high-density and resource-poor countries (Aggarwal and Goel 2015). Epidemics may also occur after the accidental introduction of HAV to areas with better sanitation but susceptible population (Jacobsen and Wiersma 2010). HAV is a positive-sense, single-stranded RNA virus of the genus Hepatovirus in the family Picornaviridae (Adams et al. 2017). The genome is approximately 7500 nucleotides in length and contains a single open reading frame (ORF) encoding a polyprotein, which is divided into three regions: P1 (VP1–VP4, constituting the viral capsid), P2 (2A–2C), and P3 (3A–3D, constituting the polymerase) (Hollinger and Martin 2013). HAV has been classified as the type species of Hepatovirus (HepV), and historically humans and other...
This work was jointly funded by the National Natural Science Foundation of China (Grant No. 81290341). We also thank The Core Facility and Technical Support, Wuhan Institute of Virology for assistance in high throughput sequencing sample preparation.
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
Animal and human rights statement
This study was approved by the Animal Ethics Committee of the Wuhan Institute of Virology (Animal ethics Approval Number: WIVA05201202).
- Adams MJ, Lefkowitz EJ, King AMQ, Harrach B, Harrison RL, Knowles NJ, Kropinski AM, Krupovic M, Kuhn JH, Mushegian AR, Nibert M, Sabanadzovic S, Sanfacon H, Siddell SG, Simmonds P, Varsani A, Zerbini FM, Gorbalenya AE, Davison AJ (2017) Changes to taxonomy and the international code of virus classification and nomenclature ratified by the international committee on taxonomy of viruses. Arch Virol 162:2505–2538CrossRefPubMedGoogle Scholar
- Drexler JF, Corman VM, Lukashev AN, van den Brand JM, Gmyl AP, Brunink S, Rasche A, Seggewibeta N, Feng H, Leijten LM, Vallo P, Kuiken T, Dotzauer A, Ulrich RG, Lemon SM, Drosten C, Hepatovirus Ecology C (2015) Evolutionary origins of hepatitis a virus in small mammals. Proc Natl Acad Sci USA 112:15190–15195CrossRefPubMedPubMedCentralGoogle Scholar
- Hollinger FB, Martin A (2013) Hepatitis a virus. In: Kluwer W (ed) Field’s virology, vol 6. Lippincott Williams & Wilkins, Philadelphia, pp 550–581Google Scholar
- WHO (2017) Global hepatitis report 2017. World Health Organization. http://www.who.int/hepatitis/publications/global-hepatitis-report2017/en/. Accessed 23 Nov 2017