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Interfacial Polymer Brush Layer for DNA Sensors Based on Graphene Transistors

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Abstract

Graphene field-effect transistors (FETs) provide an efficient platform for enabling the label-free detection of DNA molecules. In this study, we used an interfacial polymer brush layer, which is inserted between graphene and SiO2, to enhance the electrical properties of the DNA sensors based on graphene FETs. When a polymer brush with no net dipole moment was used as a surface modification layer of SiO2, high field-effect mobility and stability were obtained in graphene FETs. In addition, it was confirmed that the graphene FETs exhibited stable operation in aqueous environments. To examine the response of DNA sensors based on graphene FETs, four types of DNA oligomers with homogeneous nucleotides (i.e. 12mer of adenine, thymine, cytosine, and guanine) were consecutively dropped onto the graphene surface and changes of electrical properties in the graphene FETs were monitored after complete drying of DNA solutions. These DNA oligomers n-doped the graphene due to the electron-rich characteristics of the nucleobases. In addition, electron and hole mobilities decreased gradually upon the addition of DNA solution because DNA molecules served as charged impurities. Graphene FETs with polymer brush provide a platform for detecting DNA molecules with low concentration.

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Author notes

  1. These authors contribute equally to this work.

Authors and Affiliations

  1. Department of Organic and Nano System Engineering, Konkuk University, Seoul, 05029, Korea

    Gwang Mo Ku, Jin Woo Kim, Seunghyun Kim & Wi Hyoung Lee

  2. Department of Chemical and Biological Engineering, Sookmyung Women’s University, Seoul, 04310, Korea

    Yoon-ha Jang & Kwang-il Lim

Authors
  1. Gwang Mo Ku
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  2. Jin Woo Kim
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  3. Yoon-ha Jang
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  4. Seunghyun Kim
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  5. Kwang-il Lim
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  6. Wi Hyoung Lee
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Correspondence to Wi Hyoung Lee.

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Ku, G.M., Kim, J.W., Jang, Yh. et al. Interfacial Polymer Brush Layer for DNA Sensors Based on Graphene Transistors. Fibers Polym 19, 2483–2488 (2018). https://doi.org/10.1007/s12221-018-8608-y

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  • DOI: https://doi.org/10.1007/s12221-018-8608-y

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