Blood Pressure Change in Intrafascicular Vagal Activities

Abstract

Baroreflex plays a significant role in modulating blood pressure for the human body. It is known that activation of the vagal nerve related to baroreflex can lead to reductions of blood pressure. However, how the vagal activities quantitatively relate with blood pressure can hardly be achieved. Here fine carbon nanotube yarn (CNTy) electrodes were adopted for recording intrafascicular vagal activities, synchronized with measurement of arterial blood pressure in a rat. Together with a novel algorithm, the results preliminarily quantified that there were six clusters of neural spikes within recorded vagal activities, and the number of individual vagal spikes correspondingly varied with blood pressure. Especially for Cluster 2, the neural activations decreased with arterial blood pressure increasing. This study can shed lights on the quantified neural mechanism underlying the control of vagal activities on blood pressure, and guide the vagal-nerve neuromodulation for treating hypertension.

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Acknowledgement

The authors would like to thank Prof. ZHANG Xiaohua from Donghua University for strong help in CNT yarns, Mr. YANG Chaoman and Ms. CHEN Yan from Suzhou for PC insulation, Prof. XU Tingyan and HUANG Jun from Shanghai Institute of Hypertension, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Prof. ZHANG Yuanting from City University of Hong Kong for advice in vagal recording, and Master YU Xiao for help in CNTy electrodes.

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Correspondence to Jiguang Wang 王继光 or Xiaohong Sui 隋晓红.

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Foundation item

the Innovation Studio from School of Biomedical Engineering, Shanghai Jiao Tong University, and the Medical-Engineering Cross Project of Shanghai Jiao Tong University (No. YG2017MS53)

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Guo, J., Li, R., Wang, J. et al. Blood Pressure Change in Intrafascicular Vagal Activities. J. Shanghai Jiaotong Univ. (Sci.) 26, 47–54 (2021). https://doi.org/10.1007/s12204-021-2259-7

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Key words

  • vagal nerve
  • hypertension
  • baroreflex
  • signal processing
  • neuromodulation
  • carbon nanotube yarn (CNTy) electrodes

CLC number

  • R 318

Document code

  • A