Numerical method for axial motion artifact correction in retinal spectral-domain optical coherence tomography

Abstract

A numerical method that compensates image distortions caused by random fluctuations of the distance to an object in spectral-domain optical coherence tomography (SD OCT) has been proposed and verified experimentally. The proposed method is based on the analysis of the phase shifts between adjacent scans that are caused by micrometer-scale displacements and the subsequent compensation for the displacements through phase-frequency correction in the spectral space. The efficiency of the method is demonstrated in model experiments with harmonic and random movements of a scattering object as well as during in vivo imaging of the retina of the human eye.

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Acknowledgements

This work was supported by the State task for IAP RAS (project No. 0035-2019-0013) in part of method development by the Russian scientific foundation (project No. 17-15-01507) in part of model experiments and setup creating, the Russian Federal target program (project 14.610.21.0014 unique No. RFMEFI61017X0014) in part of retinal imaging experiments.

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Correspondence to Pavel A. Shilyagin.

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Sergey Yu. Ksenofontov, Ph.D., Graduated Nizhny Novgorod University in 1993. Ph.D. in Engineering since 2017. Research interests: optical measurement techniques, OCT, computationally efficient algorithms. Current work: computer solutions for OCT.

Pavel A. Shilyagin, Ph.D., Graduated Nizhny Novgorod University in 2005, master of Radiophysics. Ph.D. in Radiophysics since 2009. Research interests: optical measurement techniques, OCT, optical instrumentation, medical physics. Current work: optical solutions for OCT.

Dmitry A. Terpelov, Ph.D., Graduated Nizhny Novgorod Technical University in 2004. Ph.D. in Experimental physics since 2018. Research interests: optical measurement techniques, OCT, computationally efficient algorithms. Current work: electronics for OCT.

Valentin M. Gelikonov, Ph.D., D.Sc. Graduated Nizhny Novgorod University in 1966, engineer with “Radiophysics and electronics” specialization. Scientific degree: 1985-Ph.D. 2007-D.Sc. State Prize of Russian Federation in Science and Technology, 1999. Head of department “Nano-optics and high precision optical measurements” Institute of Applied Physics at the Russian Academy of Sciences (IAP RAS). Research interests: natural fluctuations of gas laser, nonlinear laser spectroscopy, fiber-optical interferometry, high precision optical measurements, bioimaging. Current work: polarization effects in OCT, multimodal OCT.

Grigory V. Gelikonov, Ph.D., D.Sc. Graduated Nizhny Novgorod University in 1992. Ph.D. in Radiophysics since 2007, D.Sc. since 2018. Research interests: development and creation of single-mode fiber elements, laboratory and clinical imaging of animal and human tissues, experimental study of middle-infrared laser ablation of biotissue with OCT monitoring, development of improved OCT technique, including cross-polarization OCT and two-wavelength OCT. Current work: multimodal OCT, clinical OCT approaches.

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Ksenofontov, S.Y., Shilyagin, P.A., Terpelov, D.A. et al. Numerical method for axial motion artifact correction in retinal spectral-domain optical coherence tomography. Front. Optoelectron. 13, 393–401 (2020). https://doi.org/10.1007/s12200-019-0951-0

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Keywords

  • optical coherence tomography (OCT)
  • motion artifact correction
  • retinal imaging
  • numerical method