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The role of endoplasmic reticulum stress in endometriosis

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Cell Stress and Chaperones Aims and scope

Abstract

Endometriosis is a chronic gynecologic disorder characterized by abnormal growth of endometrium-like tissues in the ectopic regions of the pelvic peritoneum. The pathophysiology of endometriosis is not completely understood; however, excessive endometrial cell proliferation together with resistance to apoptosis facilitates the migration, implantation, and survival of endometrial cells in the distant sites. Endoplasmic reticulum (ER) stress response (also called unfolded protein response) is a cellular defense mechanism triggered by ER stress. When severe enough, the so-called response initiates cell suicide, i.e., apoptosis. Therefore, therapeutic induction of ER stress in endometriotic cells could promote apoptosis and contribute to the management of disease. In this review, we discuss the pathogenic role of ER stress in endometriosis and the most recent findings regarding the induction of ER stress in connection with endometriosis.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Authors and Affiliations

  1. Department of Nursing, Al-Maarif University College, Ramadi, Iraq

    Hussein Riyadh Abdul Kareem Al-Hetty

  2. Department of Biology, College of Science, Wasit University, Al-Kut, Iraq

    Ahmed Darweesh Jabbar

  3. Republican Scientific and Practical Center for Transfusiology and Medical Biotechnologies, Minsk, Belarus

    Vladimir F. Eremin

  4. College of Pharmacy, National University of Science and Technology, Nasiriyah, Dhi-Qar, Iraq

    Abeer Mohsen Jabbar

  5. Department of Medical Laboratories Techniques, Al-Mustaqbal University College, Hilla, Babylon, Iraq

    Abduladheem Turki Jalil

  6. Department of Dentistry, Bilad Alrafidain University College, Diyala, 32001, Iraq

    Ali G. Al-Dulimi

  7. Department of Internal and Preventive Veterinary Medicine, College of Veterinary Medicine, Wasit University, Al-Kut, Iraq

    Hasanain A.J. Gharban

  8. State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China

    Muhammad Usman Faryad Khan

  9. Department of Biophysics, College of Applied Sciences, University of Anbar, Ramadi, Iraq

    Marwan Mahmood Saleh

  10. College of Pharmacy, The Islamic University, Najaf, Iraq

    Marwan Mahmood Saleh

Authors
  1. Hussein Riyadh Abdul Kareem Al-Hetty
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  2. Ahmed Darweesh Jabbar
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  3. Vladimir F. Eremin
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  4. Abeer Mohsen Jabbar
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  5. Abduladheem Turki Jalil
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  6. Ali G. Al-Dulimi
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  7. Hasanain A.J. Gharban
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  8. Muhammad Usman Faryad Khan
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  9. Marwan Mahmood Saleh
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All authors contributed equally to the manuscript preparation.

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Correspondence to Abduladheem Turki Jalil.

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Al-Hetty, H.R.A.K., Jabbar, A.D., Eremin, V.F. et al. The role of endoplasmic reticulum stress in endometriosis. Cell Stress and Chaperones 28, 145–150 (2023). https://doi.org/10.1007/s12192-023-01323-2

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  • DOI: https://doi.org/10.1007/s12192-023-01323-2

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