Topical heat shock protein 70 prevents imiquimod-induced psoriasis-like inflammation in mice

  • Federico G. Seifarth
  • Julia E.-M. Lax
  • Jennifer Harvey
  • Paul E. DiCorleto
  • M. Elaine Husni
  • Unnikrishnan M. Chandrasekharan
  • Michael Tytell
Short Communication
  • 58 Downloads

Abstract

Psoriasis is a chronic inflammatory skin disease with systemic manifestations and potential genetic etiology. The newest treatments utilize antibodies against one of several cytokines known to underlie the inflammatory signaling molecules that produce the skin and systemic symptoms. However, these agents must be regularly injected, and they may compromise the normal responses of the immune system. Furthermore, they do not address the causes of the abnormal immunoregulatory responses of the disease because the etiology is not yet completely understood. In this short-term treatment study, the potential anti-inflammatory activity of an alfalfa-derived Hsp70-containing skin cream (aHsp70) was tested on imiquimod (IMQ)-induced psoriasis-like lesions in wild-type mice. Treatment of the mice with the aHsp70 skin cream simultaneously with the imiquimod application mitigated the induction of psoriatic-like lesions and correlated with altered expression of various skin cytokines.

Keywords

Hsp70 Alfalfa Psoriasis Skin cream Anti-inflammatory 

Notes

Compliance with ethical standards

All experiments were approved by the institutional animal care and use.

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Copyright information

© Cell Stress Society International 2018

Authors and Affiliations

  1. 1.Department of Pediatric SurgeryCleveland Clinic Children’s HospitalClevelandUSA
  2. 2.Department of Pediatric SurgeryKalispell Regional HealthcareKalispellUSA
  3. 3.Alfa Biogene International B.V.BaarnThe Netherlands
  4. 4.Department of Cellular and Molecular MedicineCleveland Clinic Lerner Research Institute and Cleveland Clinic Lerner College of Medicine of Case Western Reserve UniversityClevelandUSA
  5. 5.Department of Rheumatic and Immunologic DiseasesCleveland ClinicClevelandUSA
  6. 6.Division of Research and Sponsored ProgramsKent State UniversityKentUSA
  7. 7.Department of Neurobiology and AnatomyWake Forest University School of MedicineWinston-SalemUSA

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