Acquired pure red cell aplasia is a rare condition characterized by normocytic normochromic anemia with severe reticulocytopenia. In refractory acquired pure red cell aplasia, the low response rate of immunosuppressive therapy also constitutes a challenge. We herein report the case of a 58-year-old male with refractory acquired pure red cell aplasia that was successfully treated by eltrombopag at a dose of 75 mg/day. After application of eltrombopag, the patient achieved complete remission and tolerated the treatment very well, with only mild bilirubin elevation. These preliminary findings showed that eltrombopag may be effective and well tolerated in adult patients with refractory acquired pure red cell aplasia.
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This study was supported by State Administration of Traditional Chinese Medicine Industry Specialty (No.201407001-4), National Public Health Grand Research Foundation (No.201202017), Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institute (No. JX10231801), and Project Funded by Jiangsu Provincial Special Program of Medical Science (No. BL2014086).
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Liu, X., Cheng, L., He, Y. et al. Eltrombopag restores erythropoiesis in refractory adult acquired pure red cell aplasia. Int J Hematol (2021). https://doi.org/10.1007/s12185-021-03100-2
- Pure red cell aplasia
- Immunosuppressive therapy