International Journal of Hematology

, Volume 110, Issue 3, pp 265–271 | Cite as

JSH practical guidelines for hematological malignancies, 2018: II. Lymphoma-6. Burkitt lymphoma (BL)

  • Kenichi IshizawaEmail author


Burkitt lymphoma (BL) is a highly aggressive mass-forming B-cell lymphoma. It was listed as “Burkitt lymphoma/leukemia” through the third edition of the WHO Classification [1], but L3 acute lymphoblastic leukemia in the FAB classification is synonymous with Burkitt leukemia, and, thus, the listed name was changed to “Burkitt lymphoma” in the fourth edition of the WHO Classification (2008), and Burkitt lymphoma with leukemic features was classified under the clinical BL subtype “Burkitt leukemia variant [2].” In the revised fourth edition of the WHO Classification (2017), the category for acute lymphoid leukemia was changed from “lymphoid neoplasms” to “myeloid neoplasms and acute leukemia,” but BL remained classified as a mature B-cell neoplasm in the lymphoid neoplasm category as before. The three known clinical types of BL are endemic BL, which is prevalent in African children (Epstein–Barr virus is detected in tumor cells in a majority of patients), sporadic BL, which is...


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© Japanese Society of Hematology 2019

Authors and Affiliations

  1. 1.Department of Third Internal Medicine, Division of Hematology and Cell TherapyYamagata University Faculty of MedicineYamagataJapan

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