International Journal of Hematology

, Volume 110, Issue 3, pp 306–312 | Cite as

Post-treatment improvement of NK cell numbers predicts better survival in myeloma patients treated with thalidomide-based regimens

  • Jorge Vela-OjedaEmail author
  • Miriam America García-Ruiz Esparza
  • Abraham Majluf-Cruz
  • Jaime García-Chavez
  • Laura Arcelia Montiel-Cervantes
  • Elba Reyes-Maldonado
  • Alvaro Hernandez-Caballero
  • Maria Guadalupe Rodríguez-González
Original Article


Multiple myeloma (MM) is a disease characterized by antitumoral immune dysfunction. The objective of the present study was to determine lymphocyte subsets (B, T, NK, NKT, iNKT, dendritic cells, and regulatory T cells) in 68 newly diagnosed patients and 113 healthy donors. Lymphocyte subsets were studied in the same patients 6 months after treatment. Pre-treatment values of CD4+ T cells, NK cells, type 2 dendritic cells, and B cells in MM patients were lower than in healthy donors. Forty patients (59%) received MPT treatment and 28 (41%) thal–dex. Patients with no response to treatment, exhibited a decrease in CD4+ T cells and NK cells, as well as an increase in Treg cell numbers. Median DFS and OS was lower in patients not achieving response, in patients having low numbers of NK cells, and higher values of LDH. The number of CD4 T cells, NK, DC2, and B cells at diagnosis is lower in patients with MM. Non-responder patients had lower CD4 and NK, but higher Treg cell values. Patients in which response is not achieved, and those holding lower values of NK cells and higher levels of LDH, have poor DFS and OS.


Myeloma NK cells Treg cells LDH Prognostic factors 



This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.


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Copyright information

© Japanese Society of Hematology 2019

Authors and Affiliations

  • Jorge Vela-Ojeda
    • 1
    • 2
    • 4
    Email author
  • Miriam America García-Ruiz Esparza
    • 1
  • Abraham Majluf-Cruz
    • 3
  • Jaime García-Chavez
    • 1
    • 2
  • Laura Arcelia Montiel-Cervantes
    • 1
    • 2
    • 4
  • Elba Reyes-Maldonado
    • 4
  • Alvaro Hernandez-Caballero
    • 1
  • Maria Guadalupe Rodríguez-González
    • 1
  1. 1.Hematology DepartmentUMAE Especialidades Centro Médico Nacional La Raza, Instituto Mexicano del Seguro SocialMexico CityMexico
  2. 2.Unidad de Investigación de Medicina Traslacional en Enfermedades Hemato-Oncologicas, UMAE Especialidades Centro Médico Nacional La Raza, Instituto Mexicano del Seguro SocialMexico CityMexico
  3. 3.Unidad de Investigación Medica en Trombosis, Hemostasia y Aterogenesis Hospital Carlos Mc Gregor, Instituto Mexicano del Seguro SocialMexico CityMexico
  4. 4.Escuela Nacional de Ciencias Biologicas, Instituto Politecnico NacionalMexico CityMexico

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