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International Journal of Hematology

, Volume 110, Issue 3, pp 375–380 | Cite as

Transformation of follicular lymphoma to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma

  • Taisuke Narazaki
  • Yasuhiro Nakashima
  • Yasuhiro Tsukamoto
  • Mariko Tsuda
  • Toru Masuda
  • Daisaku Kimura
  • Akiko Takamatsu
  • Koichi Ohshima
  • Motoaki ShiratsuchiEmail author
  • Yoshihiro Ogawa
Case Report

Abstract

The frequency of multiple primary malignant neoplasms (MPMN) is increasing due to population aging. Since consensus guidelines for the treatment of MPMN are lacking, treatment strategies are determined by disease status on a per-patient basis. In this report, we describe a case of MPMN with follicular lymphoma (FL) grade 1 that transformed to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma. A 64-year-old woman was diagnosed with MPMN of FL and endometrioid carcinoma by staging laparotomy and lymph node biopsy. She received four cycles of adjuvant chemotherapy (carboplatin and paclitaxel) for endometrioid carcinoma, but during chemotherapy, the FL grade 1 transformed to double-hit lymphoma. We speculate that adjuvant chemotherapy for endometrioid carcinoma may have triggered the transformation of FL in the present case.

Keywords

Follicular lymphoma Transformation Double-hit lymphoma Multiple primary malignant neoplasms 

Notes

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Japanese Society of Hematology 2019

Authors and Affiliations

  • Taisuke Narazaki
    • 1
  • Yasuhiro Nakashima
    • 1
  • Yasuhiro Tsukamoto
    • 1
  • Mariko Tsuda
    • 1
  • Toru Masuda
    • 1
  • Daisaku Kimura
    • 1
  • Akiko Takamatsu
    • 1
  • Koichi Ohshima
    • 2
  • Motoaki Shiratsuchi
    • 1
    Email author
  • Yoshihiro Ogawa
    • 1
  1. 1.Department of Medicine and Bioregulatory Science, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  2. 2.Department of PathologyKurume University School of MedicineKurumeJapan

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