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Transformation of follicular lymphoma to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma

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Abstract

The frequency of multiple primary malignant neoplasms (MPMN) is increasing due to population aging. Since consensus guidelines for the treatment of MPMN are lacking, treatment strategies are determined by disease status on a per-patient basis. In this report, we describe a case of MPMN with follicular lymphoma (FL) grade 1 that transformed to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma. A 64-year-old woman was diagnosed with MPMN of FL and endometrioid carcinoma by staging laparotomy and lymph node biopsy. She received four cycles of adjuvant chemotherapy (carboplatin and paclitaxel) for endometrioid carcinoma, but during chemotherapy, the FL grade 1 transformed to double-hit lymphoma. We speculate that adjuvant chemotherapy for endometrioid carcinoma may have triggered the transformation of FL in the present case.

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Authors and Affiliations

  1. Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Taisuke Narazaki, Yasuhiro Nakashima, Yasuhiro Tsukamoto, Mariko Tsuda, Toru Masuda, Daisaku Kimura, Akiko Takamatsu, Motoaki Shiratsuchi & Yoshihiro Ogawa

  2. Department of Pathology, Kurume University School of Medicine, Kurume, Japan

    Koichi Ohshima

Authors
  1. Taisuke Narazaki
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  2. Yasuhiro Nakashima
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  3. Yasuhiro Tsukamoto
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  4. Mariko Tsuda
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  5. Toru Masuda
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  6. Daisaku Kimura
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  10. Yoshihiro Ogawa
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Correspondence to Motoaki Shiratsuchi.

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Narazaki, T., Nakashima, Y., Tsukamoto, Y. et al. Transformation of follicular lymphoma to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma. Int J Hematol 110, 375–380 (2019). https://doi.org/10.1007/s12185-019-02656-4

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  • DOI: https://doi.org/10.1007/s12185-019-02656-4

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