Impact of treatment-related weight changes from diagnosis to hematopoietic stem-cell transplantation on clinical outcome of acute myeloid leukemia
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We hypothesized that treatment-related weight loss is associated with worse outcomes following HSCT. Overall, 184 patients with AML who underwent induction therapy were classified according to d-BMI (BMI at transplant minus BMI at diagnosis) (kg/m2) as < −2, − 2 to + 2, and > + 2. At 1 year, OS was 67.9% (95% CI, 60.7–74.2), DFS was 64.1% (95% CI, 56.7–70.6), and GRFS was 40.2% (95% CI, 33.1–47.2). For d-BMI groups < − 2, − 2 to + 2, and > + 2, GRFS at 1 year was 16.1% (95% CI, 5.1–31.4), 45.4% (95% CI, 36.4–53.7), and 41.7% (95% CI, 22.2–60.1), respectively (P = 0.0067). Multivariate analysis showed that both worse OS (HR, 1.78; 95% CI, 1.02–3.14; P = 0.007) and GRFS (HR, 2.34; 95% CI, 1.26–4.35; P = 0.007) were associated with reduced BMI (d-BMI < − 2). Treatment-related weight reduction in AML was associated with poor outcome after HSCT.
KeywordsAML Treatment-related weight loss BMI HSCT
I appreciate for all authors who participated in the research and preparation of the manuscript. I would like to show my deepest gratitude to my supervisor, Dr. Etsuko-Yamazaki, Dr. Shin-Fujisawa, Dr. Heiwa-Kanamori, and Prof. Hideaki-Nakajima. This work was supported by Yokohama Cooperative Study Group for Hematology (YACHT).
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Conflict of interest
The authors declare that they have no conflict of interest. A summary of relevant information will be published with the manuscript.
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