International Journal of Hematology

, Volume 109, Issue 5, pp 509–538 | Cite as

JSH practical guidelines for hematological malignancies, 2018: III. Myeloma-1. Multiple myeloma (MM)

  • Shinsuke IidaEmail author
  • Tadao Ishida
  • Hirokazu Murakami
  • Shuji Ozaki
  • Masahiro Abe
  • Hiroyuki Hata
  • Chihiro Shimazaki
Guide Line


Multiple myeloma (MM) is a disease characterized by monoclonal (neoplastic) proliferation of plasma cells and increased levels of the plasma cell product monoclonal immunoglobulin (M-protein) in serum and urine [1]. In Japan, its incidence is approximately 5 per 100,000 population and it causes approximately 4000 deaths per year. It accounts for approximately 1% of all malignancies and approximately 10% of all hematopoietic tumors, and its incidence and mortality rate are increasing every year. Criteria by the International Myeloma Working Group (IMWG) are widely used in its diagnosis (Table 1) [2, 3].

Table 1 IMWG criteria for the diagnosis of plasma cell neoplasms

Non-IgM monoclonal gammopathy of undetermined significance (MGUS)

(1) Serum non-IgM M-protein < 3 g/dL

(2) Clonal bone marrow plasma cells < 10%

(3) Absence of end-organ damage (CRAB or amyloidosis)

Meets all the criteria in (1) through (3)

IgM monoclonal gammopathy of undetermined significance (MGUS)

(1) Serum IgM...

Copyright information

© Japanese Society of Hematology 2019

Authors and Affiliations

  • Shinsuke Iida
    • 1
    Email author
  • Tadao Ishida
    • 2
  • Hirokazu Murakami
    • 3
  • Shuji Ozaki
    • 4
  • Masahiro Abe
    • 5
  • Hiroyuki Hata
    • 6
  • Chihiro Shimazaki
    • 7
  1. 1.Department of Hematology and OncologyNagoya City University Graduate School of Medical SciencesNagoyaJapan
  2. 2.Department of HematologyJapanese Red Cross Medical CenterTokyoJapan
  3. 3.Laboratory SciencesGunma University Graduate School of Health SciencesMaebashiJapan
  4. 4.Department of HematologyTokushima Prefectural Central HospitalTokushima-shiJapan
  5. 5.Department of Hematology, Endocrinology, and Metabolism Institute of Biomedical SciencesTokushima University Graduate SchoolTokushimaJapan
  6. 6.Division of Informative Clinical Sciences Faculty of Medical SciencesKumamoto UniversityKumamotoJapan
  7. 7.Japan Community Health Care Organization Kyoto Kuramaguchi Medical CenterKyoto-shiJapan

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