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International Journal of Hematology

, Volume 109, Issue 5, pp 572–577 | Cite as

Light-chain plasma cell myeloma caused by 14q32/IGH translocation and loss of the other allele

  • Yuji Nishio
  • Hirotaka SakaiEmail author
  • Yusuke Saiki
  • Akiko Uchida
  • Yu Uemura
  • Manabu Matsunawa
  • Yasushi Isobe
  • Masayuki Kato
  • Naoto Tomita
  • Ikuo Miura
Original Article
  • 68 Downloads

Abstract

Light-chain plasma cell myeloma (LC-PCM) is a PCM subtype in which only immunoglobulin light-chain is secreted. However, the absence of immunoglobulin heavy-chain (IGH) production in this condition has not been fully elucidated. To address this issue, we retrospectively analyzed patients at our center with LC-PCM and found a group who had only split signals of IGH gene derived from 14q32/IGH translocations by fluorescence in situ hybridization (FISH). Six patients were identified with only split signals of the IGH gene derived from 14q32/IGH translocations. Five of these patients were newly diagnosed, while one had IgG-λ PCM at presentation, which transformed to λ LC-PCM after treatment. The translocation partners were identified in four patients: two cases of (11;14)(q13;q32) and two cases of (4;14)(p16;q32). The development of LC-PCM appears to be explained by the application of allelic exclusion in these patients, such that 14q32/IGH translocation in one allele contributes to the pathogenesis of PCM and the subsequent loss of the other allele is responsible for the loss of IGH production. These findings suggest that a FISH pattern of IGH with “split and loss” may constitute a unique subgroup of LC-PCM.

Keywords

Immunoglobulin heavy-chain Chromosomal translocation Class switch recombination Allelic exclusion Bence Jones protein 

Notes

Compliance with ethical standards

Conflict of interest

I.M. is a consultant for SRL, Inc.

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Copyright information

© Japanese Society of Hematology 2019

Authors and Affiliations

  1. 1.Division of Hematology and Oncology, Department of Internal MedicineSt. Marianna University School of MedicineKawasakiJapan

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