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International Journal of Hematology

, Volume 109, Issue 4, pp 440–450 | Cite as

Optimal dosage of methotrexate for GVHD prophylaxis in umbilical cord blood transplantation

  • Yoshitaka AdachiEmail author
  • Kazutaka Ozeki
  • Shun Ukai
  • Ken Sagou
  • Nobuaki Fukushima
  • Akio Kohno
Original Article
  • 179 Downloads

Abstract

The combination of methotrexate (MTX) and a calcineurin inhibitor is widely used for GVHD prophylaxis in umbilical cord blood transplantation (UCBT). However, the optimal MTX dosage for GVHD prophylaxis in UCBT remains unclear. In the present study, we investigated the impact of MTX dosage on clinical outcomes following UCBT in a single-center retrospective study. Of 70 UCBT recipients included in this study, 37 received MTX at doses of 10 mg/m2 on day 1, and 7 mg/m2 on days 3 and 6 (low-dose MTX: LD-MTX), and 33 received MTX at doses of 15 mg/m2 on day 1, and 10 mg/m2 on days 3 and 6 (standard-dose MTX: SD-MTX), in addition to tacrolimus (TAC). Grade 3–4 acute GVHD and/or transplant-related complications with endothelial cell damage were considered severe transplant-related complications. Univariate analysis findings revealed that the risk of grade 3–4 acute GVHD was significantly lower in the SD-MTX group than in the LD-MTX group (P = 0.013). Multivariate analysis findings revealed that SD-MTX was significantly associated with a lower incidence of severe transplant-related complications (HR = 0.25; 95% CI, 0.07–0.87; P = 0.029). We conclude that SD-MTX in combination with tacrolimus is optimal for GVHD prophylaxis in UCBT.

Keywords

Methotrexate Graft-versus-host disease Umbilical cord blood transplantation Endothelial cell damage 

Notes

Acknowledgements

The authors acknowledge all the physicians, nurses, and other staff who participated in the care of the patients in the Department of Hematology and Oncology at Konan Kosei Hospital.

Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest.

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Copyright information

© Japanese Society of Hematology 2019

Authors and Affiliations

  1. 1.Department of Hematology and OncologyKonan Kosei HospitalKonanJapan

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