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Invasive Scopulariopsis alboflavescens infection in patient with acute myeloid leukemia

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Abstract

Scopulariopsis alboflavescens is a soil saprophyte that is widely distributed in nature. Recently, there have been increasing number of reports of invasive infections with Scopulariopsis species in immunocompromised patients. In this report, we described an adult woman with acute myeloid leukemia and who developed S. alboflavescens pneumonia. Liposomal amphotericin B and voriconazole combination therapy was unsuccessful and the patient died because of pneumonia. Scopulariopsis is highly resistant to available antifungal agents and almost invariably fatal. This case report should alert clinicians to the importance of listing Scopulariopsis as a pathogenic fungus in immunocompromised patients.

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Authors and Affiliations

  1. Department of Medical Oncology and Hematology, Kobe University Hospital, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan

    Keiji Kurata, Hiroya Ichikawa, Rina Sakai, Yu Mizutani, Kei Takenaka, Seiji Kakiuchi, Yoshiharu Miyata, Akihito Kitao, Kimikazu Yakushijin, Katsuya Yamamoto, Mitsuhiro Ito, Hiroshi Matsuoka & Hironobu Minami

  2. Division of Infectious Diseases, Kobe University Hospital, Kobe, Japan

    Sho Nishimura

  3. Department of Transfusion Medicine and Cell Therapy, Kobe University Hospital, Kobe, Japan

    Shinichiro Kawamoto

  4. Department of Infection Control and Prevention, Kobe University Hospital, Kobe, Japan

    Issei Tokimatsu

  5. Medical Mycology Research Center, Chiba University, Chiba, Japan

    Katsuhiko Kamei

Authors
  1. Keiji Kurata
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  2. Sho Nishimura
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  13. Mitsuhiro Ito
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  14. Hiroshi Matsuoka
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  17. Hironobu Minami
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Correspondence to Keiji Kurata.

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Kurata, K., Nishimura, S., Ichikawa, H. et al. Invasive Scopulariopsis alboflavescens infection in patient with acute myeloid leukemia. Int J Hematol 108, 658–664 (2018). https://doi.org/10.1007/s12185-018-2496-1

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  • DOI: https://doi.org/10.1007/s12185-018-2496-1

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