International Journal of Hematology

, Volume 108, Issue 1, pp 30–38 | Cite as

PAS positivity of erythroid precursor cells is associated with a poor prognosis in newly diagnosed myelodysplastic syndrome patients

  • Kenta Masuda
  • Shuichi Shiga
  • Hiroshi Kawabata
  • Akifumi Takaori-Kondo
  • Satoshi Ichiyama
  • Yasuhiko Kamikubo
Original Article

Abstract

Myelodysplastic syndrome (MDS) is a group of clonal stem cell disorders characterized by hematopoietic insufficiency. The accurate risk stratification of patients with MDS is essential for selection of appropriate therapies. We herein conducted a retrospective cohort study to examine the prognostic value of periodic acid-Schiff (PAS) reaction-positive erythroblasts in MDS patients. We examined the PAS positivity of the bone marrow erythroblasts of 144 patients newly diagnosed with MDS; 26 (18.1%) of them had PAS-positive erythroblasts, whereas 118 (81.9%) did not. The PAS-positive group showed significantly poorer karyotypes as defined in the revised International Prognostic Scoring System (IPSS-R) and higher scores in age-adjusted IPSS-R (IPSS-RA) than the PAS-negative group. Overall survival (OS) and leukemia-free survival (LFS) were also significantly shorter in the PAS-positive group than in the PAS-negative group. Similar results were obtained when only high- and very high risk groups were analyzed using IPSS-RA. This retrospective study suggested that the PAS positivity of erythroblasts is an additional prognostic factor combined with other risk scores for OS and LFS in MDS, and our results may contribute to improved clinical decision-making and rapid risk stratification.

Keywords

PAS-positive erythroblasts Myelodysplastic syndrome Prognosis International Prognostic Scoring System Revised International Prognostic Scoring System 

Notes

Compliance with ethical standards

Conflict of interest

No conflicts of interest to disclose.

Supplementary material

12185_2018_2443_MOESM1_ESM.jpg (41 kb)
Fig. S1 Distribution of percentage of the PAS-positive erythroblasts among 26 PAS-positive MDS cases. (JPEG 41 kb)
12185_2018_2443_MOESM2_ESM.pdf (106 kb)
Supplementary material 2 (PDF 106 kb)

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Copyright information

© The Japanese Society of Hematology 2018

Authors and Affiliations

  • Kenta Masuda
    • 1
  • Shuichi Shiga
    • 1
  • Hiroshi Kawabata
    • 2
    • 3
  • Akifumi Takaori-Kondo
    • 3
  • Satoshi Ichiyama
    • 4
  • Yasuhiko Kamikubo
    • 5
  1. 1.Department of Clinical LaboratoryKyoto University HospitalKyotoJapan
  2. 2.Department of Hematology and ImmunologyKanazawa Medical UniversityIshikawaJapan
  3. 3.Department of Hematology and Oncology, Graduate School of MedicineKyoto UniversityKyotoJapan
  4. 4.Department of Clinical Laboratory Medicine, Graduate School of MedicineKyoto UniversityKyotoJapan
  5. 5.Human Health Science, Graduate School of MedicineKyoto UniversityKyotoJapan

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