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CD3+ CD56+ EBER1+ atypical extraosseous plasmacytoma of the nasal cavity

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Abstract

We present a case of atypical extraosseous plasmacytoma (EP) with a plasmablastic morphology and CD3+ CD56+ Epstein–Barr virus-encoded RNA-1 (EBER1)+ phenotypes of the nasal cavity. A 51-year-old male attended a local hospital with a tumor located in his left nasal cavity that was histologically diagnosed as extranodal NK/T cell lymphoma, nasal type. We reviewed the specimens and re-biopsied the tumor, and confirmed that the tumor was positive for CD3, CD56, and EBER1; however, the tumor showed a plasmablastic morphology without necrosis and angiocentricity, and was positive for CD138, but negative for CD20 and PAX5. Given a plasmablastic morphology and EBER1 positivity, but a relatively low Ki67 index (30%), we diagnosed the case as atypical EP. The CHOP regimen was administered and complete remission achieved. This case indicated that EP should be considered as a differential diagnosis even when a tumor shows large cell morphology and is positive for CD3, CD56, and EBER1.

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Acknowledgements

This work was supported in part by the Japan Agency for Medical Research and Development Fund (17ck0106349s0201) in Japan.

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Authors and Affiliations

  1. Division of Pathology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Yayoi Ando, Akiko Miyagi Maeshima & Hirokazu Taniguchi

  2. Department of Hematology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Yayoi Ando, Suguru Fukuhara, Shinichi Makita, Wataru Munakata, Tatsuya Suzuki, Dai Maruyama & Koji Izutsu

Authors
  1. Yayoi Ando
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  2. Akiko Miyagi Maeshima
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  3. Suguru Fukuhara
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  4. Shinichi Makita
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  5. Wataru Munakata
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  6. Tatsuya Suzuki
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  7. Dai Maruyama
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  8. Hirokazu Taniguchi
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  9. Koji Izutsu
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Corresponding author

Correspondence to Akiko Miyagi Maeshima.

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The authors declare that they have no competing interests.

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Ando, Y., Maeshima, A.M., Fukuhara, S. et al. CD3+ CD56+ EBER1+ atypical extraosseous plasmacytoma of the nasal cavity. Int J Hematol 108, 344–347 (2018). https://doi.org/10.1007/s12185-018-2438-y

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  • DOI: https://doi.org/10.1007/s12185-018-2438-y

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