Vitamin C deficiency: rare cause of severe anemia with hemolysis
- 192 Downloads
Historically known to be a disease of sailors and soldiers in the seventeenth and eighteenth century, scurvy is a rare nutritional deficiency in the developed world, but it can still be seen among the alcoholics and the malnourished. We present a case of a 39-year-old alcoholic male who presented with progressive fatigue and diffuse purpuric rash with scattered ecchymosis for 2 months. Blood work was remarkable for hemoglobin of 9.1 g/dl, which further dropped to 7 g/dl over the next few days. He was then found to have hemolysis on lab work. After an extensive workup, the common causes of hemolytic anemia were ruled out, vitamin C level was checked, which interestingly resulted as 0 mg/dl. Supplementation with oral vitamin C resulted in the gradual resolution of hemolytic anemia and rash. Hemoglobin improved to 15 g/dl in 4 weeks, with normalization of vitamin C level. The clinical features of scurvy can easily be confused with conditions such as vasculitis, deep venous thrombosis, and systemic bleeding disorders. Therefore, comprehensive workup up is required prior to the diagnosis. Although rare, being a reversible condition, early diagnosis and treatment of scurvy in high-risk populations cannot be stressed enough.
KeywordsScurvy Hemolytic anemia Vitamin C deficiency Rash Petechia
Activated partial thromboplastin time
Red blood cell
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests to disclose.
- 6.Major RH, A history of medicine. A history of medicine. Charles C. Thomas; 1954.Google Scholar
- 7.Lind J, A treatise on the scurvy: in three parts, containing an inquiry into the nature, causes, and cure, of that disease. A. Millar; 1757.Google Scholar
- 10.Padayatty SJ, Levine M. New insights into the physiology and pharmacology of vitamin C. Cmaj. 2001;164(3):353–5.Google Scholar
- 12.Cox EV. The Anemia of Scurvy. In: Harris RS, Wool IG, Loraine JA, Thimann KV (eds). Vitamins & hormones. Cambridge: Academic Press, 1969, pp 635–652.Google Scholar
- 13.Goldberg A. The anaemia of scurvy. Q J Med. 1963;32:51–64.Google Scholar
- 14.Stefanini M, Dameshek W. The hemorrhagic disorders. New York: Grune & Stratton. Inc; 1955.Google Scholar
- 17.Vilter RW, Woolford RM, Spies TD. Severe scurvy; a clinical and hematologic study. J Lab Clin Med. 1946;31:609–30.Google Scholar