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Hematopoietic stem cell transplantation for subcutaneous panniculitis-like T-cell lymphoma: single center experience in an Asian population

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Abstract

Subcutaneous panniculitis-like T-cell lymphoma (SPTL) is a rare form of cytotoxic T-cell lymphoma. It is believed that SPTL in patients without hemophagocytic syndrome (HPS) follows an indolent course; in contrast, SPTL in patients with HPS has been associated with unfavorable survival. To provide more clinical data on SPTL in Asian populations and to identify optimal therapeutic strategies for SPTL, we assessed the clinicopathological features and long-term follow-up data of 10 Taiwanese SPTL patients diagnosed at a single center. Our study demonstrates a group of patients with high incidence of HPS (50%), rather aggressive courses, and early progression. A total of eight patients underwent hematopoietic stem cell transplant (HSCT), including one autologous HSCT and seven allogeneic HSCT. Seven of eight patients receiving HSCT achieved durable remission and maintained in remission for over 30 months (range 30–132 months). There was no difference in 3-year survival of patients with HPS (80%) compared with patients without HPS (80%). Of long-term survivors in the HPS group, three of four received HSCT (autologous HSCT, n = 1; allogeneic HSCT, n = 2). Our study indicated that HSCT is a curative option for eligible SPTL patients with HPS.

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Acknowledgements

This work was partially supported by grants from Taipei Veterans General Hospital (V107C-192, VGHUST107-G3-1-2) and Chong Hin Loon Memorial Cancer and Biotherapy Research Cancer, National Yang-Ming University. The funding sources had no role in the study design or conduct, or in the decision to submit it for publication.

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Authors and Affiliations

  1. Division of Hematology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec 2, Shih-Pai Road, Taipei, 112, Taiwan

    Ting-An Lin, Yao-Chung Liu, Jin-Hwang Liu, Liang-Tsai Hsiao, Chia-Jen Liu, Hao-Yuan Wang, Po-Shen Ko & Jyh-Pyng Gau

  2. Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

    Ching-Fen Yang

  3. Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan

    Ching-Fen Yang, Yao-Chung Liu, Jin-Hwang Liu, Tzeon-jye Chiou, Liang-Tsai Hsiao, Hsiu-Ju Yen, Chia-Jen Liu, Hao-Yuan Wang, Po-Shen Ko, Sheng-Hsuan Chien & Jyh-Pyng Gau

  4. Division of Transfusion Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

    Tzeon-jye Chiou & Sheng-Hsuan Chien

  5. Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan

    Hsiu-Ju Yen

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  1. Ting-An Lin
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Contributions

TAL coordinated the study, performed the statistical analysis, and wrote the paper; JPG designed the study, interpreted data and critically revised the manuscript; C.F.Y reviewed histopathology findings and performed immunohistochemical stains; all authors: collected clinical, laboratory, and histology data. All authors gave final approval to the manuscript.

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Correspondence to Jyh-Pyng Gau.

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Lin, TA., Yang, CF., Liu, YC. et al. Hematopoietic stem cell transplantation for subcutaneous panniculitis-like T-cell lymphoma: single center experience in an Asian population. Int J Hematol 109, 187–196 (2019). https://doi.org/10.1007/s12185-018-02568-9

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  • DOI: https://doi.org/10.1007/s12185-018-02568-9

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