References
Göllner S, Oellerich T, Agrawal-Singh S, Schenk T, Klein H-U, Rohde C, et al. Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia. Nat Med. 2017;23:69–78.
Kikuchi J, Koyama D, Wada T, Izumi T, Hofgaard PO, Bogen B, Furukawa Y. Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma. J Clin Investig. 2015;125:4375–90.
Matsunaga T, Takemoto N, Sato T, Takimoto R, Tanaka I, Fujimi A, et al. Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia. Nat Med. 2003;9:1158–65.
Acknowledgements
This work was supported in part by the High-Tech Research Center Project for Private Universities: Matching Fund Subsidy from MEXT, a Grant-in-Aid for Scientific Research from JSPS, and research Grants from the Japan Leukemia Research Fund, Yasuda Memorial Cancer Foundation, Takeda Science Foundation, Novartis Foundation (to JK and YF), Mitsui Life Social Welfare Foundation and SENSHIN Medical Research Foundation (to JK). JK and YF received the Kano Foundation Research Grant and the Kobayashi Foundation Cancer Research Award, respectively.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare no competing financial interests.
Electronic supplementary material
Below is the link to the electronic supplementary material.
About this article
Cite this article
Kikuchi, J., Kuroda, Y., Koyama, D. et al. Cell adhesion-induced phosphorylation and inactivation of EZH2 confer drug resistance to acute myeloid leukemia cells. Int J Hematol 107, 383–385 (2018). https://doi.org/10.1007/s12185-017-2376-0
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12185-017-2376-0