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Cell adhesion-induced phosphorylation and inactivation of EZH2 confer drug resistance to acute myeloid leukemia cells

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References

  1. Göllner S, Oellerich T, Agrawal-Singh S, Schenk T, Klein H-U, Rohde C, et al. Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia. Nat Med. 2017;23:69–78.

    Article  PubMed  Google Scholar 

  2. Kikuchi J, Koyama D, Wada T, Izumi T, Hofgaard PO, Bogen B, Furukawa Y. Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma. J Clin Investig. 2015;125:4375–90.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Matsunaga T, Takemoto N, Sato T, Takimoto R, Tanaka I, Fujimi A, et al. Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia. Nat Med. 2003;9:1158–65.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

This work was supported in part by the High-Tech Research Center Project for Private Universities: Matching Fund Subsidy from MEXT, a Grant-in-Aid for Scientific Research from JSPS, and research Grants from the Japan Leukemia Research Fund, Yasuda Memorial Cancer Foundation, Takeda Science Foundation, Novartis Foundation (to JK and YF), Mitsui Life Social Welfare Foundation and SENSHIN Medical Research Foundation (to JK). JK and YF received the Kano Foundation Research Grant and the Kobayashi Foundation Cancer Research Award, respectively.

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Correspondence to Yusuke Furukawa.

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Kikuchi, J., Kuroda, Y., Koyama, D. et al. Cell adhesion-induced phosphorylation and inactivation of EZH2 confer drug resistance to acute myeloid leukemia cells. Int J Hematol 107, 383–385 (2018). https://doi.org/10.1007/s12185-017-2376-0

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  • DOI: https://doi.org/10.1007/s12185-017-2376-0

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